Ignite Creation Date:
2024-05-05 @ 11:19 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001747
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Racial Differences in Control of Blood Vessel Tone and Blood Flow
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Racial Differences in Flow Mediated Vasodilator Function
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Black Americans tend to die more often from and have more diseases associated with heart disease than White Americans The exact cause of this is unknown but it is likely a combination of genetics behavior risk factors strategies for education and prevention and socioeconomic factors
Recent studies have suggested that faster biological processes in blood vessels of Black Americans may be the cause of increased amounts of heart disease In addition small blood vessels in Black Americans seem to be less responsive to substances that relax blood vessels which may explain increased blood pressure levels
In this study researchers plan to study artery relaxation dilation in response substances affecting the cells lining blood vessels endothelin Researchers will compare the results of this study in black and white people to find out whether racial differences may contribute to increases in heart disease and heart related deaths in blacks
Recent studies have suggested that faster biological processes in blood vessels of Black Americans may be the cause of increased amounts of heart disease In addition small blood vessels in Black Americans seem to be less responsive to substances that relax blood vessels which may explain increased blood pressure levels
In this study researchers plan to study artery relaxation dilation in response substances affecting the cells lining blood vessels endothelin Researchers will compare the results of this study in black and white people to find out whether racial differences may contribute to increases in heart disease and heart related deaths in blacks
Detailed Description:
Black Americans have a greater morbidity and mortality related to cardiovascular diseases compared to whites The cause for this phenomenon is probably multifactorial and includes differences in pathogenesis risk factor patterns genetic background behavioral variables strategies for education and prevention and socioeconomic factors Recent evidence suggests that acceleration of some of the processes related to vascular biology may account for the greater prevalence of cardiovascular disease in blacks A diminished vasodilator response of the microvasculature has been shown in African Americans and may therefore be responsible for their increased prevalence of hypertension Endothelial dysfunction is a central mechanism in the development of atherosclerosis It is therefore reasonable to postulate that endothelial dysfunction of large conductance arteries may also contribute to a greater susceptibility to atherosclerosis in blacks compared to whites even in those individuals without the known risk factors for coronary heart disease In the present study we propose to investigate brachial artery dilation in response to endothelium-dependent and -independent stimuli in black and white individuals to determine whether racial differences in the vascular biology of large conductance vessels that might contribute to the greater cardiovascular morbidity and mortality previously reported in blacks
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 98-H-0112 | None | None | None |