Ignite Creation Date:
2024-05-05 @ 5:14 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00419406
Status:
COMPLETED
Last Update Posted:
2009-01-22
First Post:
2007-01-04
Brief Title:
Medium-Dose UVA1 Versus Narrow-Band UVB in Atopic Dermatitis
Sponsor:
Ruhr University of Bochum
Organization:
Ruhr University of Bochum
Study Overview
Official Title:
Medium-Dose UVA1 Versus Narrow-Band UVB Phototherapy A Randomized Double-Blind Controlled Cross-Over-Study
Status:
COMPLETED
Status Verified Date:
2009-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Atopic dermatitis AD is a very common disorder that is characterized by pruritic inflammatory skin lesions with patients usually having an individual or family history of atopic diseases in their background Phototherapy is among the first-line approaches in the management of AD In this context a variety of studies have shown a beneficial effect of natural or artificial UV radiation in atopic dermatitis AD The past ten years have seen the introduction of new phototherapeutic regimens for AD including UVA1 and NB-UVBUVA1 seems to be more effective than the above mentioned broadband spectra in particular in acute severe AD The aim of the present study is the comparison of UVA1 and NB-UVB phototherapy in the treatment of AD Additionally the course of several cytokines human beta-defensins and SMAD-proteins will be evaluated during the course of treatment
Detailed Description:
Atopic dermatitis AD is a very common disorder that is characterized by pruritic inflammatory skin lesions with patients usually having an individual or family history of atopic diseases in their background eg allergic asthma and rhinitis Defective skin barrier immunological dysfunctions type I and IV allergy genetic disorders and psychological factors contribute to the pathogenesis of AD However among these factors CD4 Th cells are reported to play a particularly crucial role in the pathogenesis of AD Phototherapy is among the first-line approaches in the management of AD In this context a variety of studies have shown a beneficial effect of natural or artificial UV radiation in atopic dermatitis AD Different broadband UV spectra BB-UVA BB-UVB BB-UVABB-UVB and combined treatment modalities such as balneophototherapy and PUVA have previously been proven to be effective in AD However the past ten years have seen the introduction of new phototherapeutic regimens for AD including UVA1 and NB-UVBUVA1 seems to be more effective than the above mentioned broadband spectra in particular in acute severe AD The aim of the present study is the comparison of UVA1 and NB-UVB phototherapy in the treatment of AD Additionally the course of several cytokines human beta-defensins and SMAD-proteins will be evaluated during the course of treatment
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None