Ignite Creation Date:
2024-05-05 @ 5:15 PM
Last Modification Date:
2024-10-26 @ 9:29 AM
Study NCT ID:
NCT00413348
Status:
UNKNOWN
Last Update Posted:
2006-12-19
First Post:
2006-12-18
Brief Title:
Type 2 Diabetes and the Effect of Probiotics
Sponsor:
Rigshospitalet Denmark
Organization:
Rigshospitalet Denmark
Study Overview
Official Title:
Effect of Probiotics on Systemic Inflammation and Insulin Resistance in Type 2 Diabetics and Healthy Controls
Status:
UNKNOWN
Status Verified Date:
2006-12
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Insulin-resistance in type 2 diabetes is associated with chronic inflammation Anti-inflammatory actions might increase sensitivity to insulin Since some probiotics have anti-inflammatory properties ingestion of the probiotic bacteria Lactobacillus Acidophilus NCFM might increase insulin-sensitivity
The inflammatory response to endotoxin injection and the insulin-sensitivity is examined before and after four weeks ingestion of probiotics
The inflammatory response to endotoxin injection and the insulin-sensitivity is examined before and after four weeks ingestion of probiotics
Detailed Description:
Numerous studies have shown an association between insulin-resistance in type 2 diabetes and chronic low-grade inflammation Some probiotics have an anti-inflammatory properties Ingestion of probiotics might therefore due to this property increase sensitivity to insulin
In this study type 2 diabetics N24 and healthy control N24 are given the probiotic bacteria Lactobacillus Acidophilus NCFM for four weeks The anti-inflammatory effect is examined by evaluating the inflammatory response White blood cell count plasma-cytokines to an iv injection of endotoxin 03 ngkg before and after the intervention Also the insulin-sensitivity is measured with an hyperinsulinemic euglycemic clamp before and after L acidophilus NCFM
In this study type 2 diabetics N24 and healthy control N24 are given the probiotic bacteria Lactobacillus Acidophilus NCFM for four weeks The anti-inflammatory effect is examined by evaluating the inflammatory response White blood cell count plasma-cytokines to an iv injection of endotoxin 03 ngkg before and after the intervention Also the insulin-sensitivity is measured with an hyperinsulinemic euglycemic clamp before and after L acidophilus NCFM
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None