Ignite Creation Date:
2024-05-06 @ 3:30 PM
Last Modification Date:
2024-10-26 @ 1:51 PM
Study NCT ID:
NCT04658433
Status:
COMPLETED
Last Update Posted:
2022-02-24
First Post:
2020-12-05
Brief Title:
The Effect of Omega -3 Supplements on the Serum Levels of ACEACE2 Ratio as a Potential Key in Cardiovascular Disease and COVID-19 A Randomized Clinical Trial in the Covid-19 Uninfected Jordanian People
Sponsor:
Applied Science Private University
Organization:
Applied Science Private University
Study Overview
Official Title:
The Effect of Omega -3 Supplements on the Serum Levels of ACEACE2 Ratio as a Potential Key in Cardiovascular Disease and COVID-19 A Randomized Clinical Trial in the COVID-19 Uninfected Jordanian People
Status:
COMPLETED
Status Verified Date:
2022-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The Renin-Angiotensin-Aldosterone System RAAS is involved in blood pressure regulation and electrolyte balance Angiotensin-converting enzyme ACE is a critical regulator of RAAS by cleaving angiotensin Ang1 to Angiotensin2 Ang2 which is the most powerful biologically active product of RAAS 1 In the same context angiotensin-converting enzyme 2 ACE2 converts Ang2 to Ang 1-7 which is a vasodilator antithrombotic and antihypertrophic peptide 2 ACE2 which is found in many tissues 3 has opposite effects to ACE on the heart kidneys and lungs 4 Many pathological conditions in particular cardiovascular disease CVD have shown a link between a disturbance in ACEACE2 ratio and the downregulation of ACE2 levels 5 Also ACEACE2 has been reported to be higher in moderate to severe chronic heart failure 6 as well as systolic blood pressure 7 Recently an elevated ACEACE2 ratio is linked to Coronavirus disease 2019 COVID-19 SARS-COV2 enters target cells by binding of the spike protein to ACE2 and a specific transmembrane serine protease 2 TMPRSS2 for the spike S protein priming which also leads to downregulation of ACE2 8 Down-regulation of ACE2 caused by Coronavirus may have a potential role in the pathogenesis of COVID-19 infection Accordingly people with a higher ACEACE2 ratio may be more at increased risk of worse Covid-19 consequences 9
On the other hand omega-3 fatty acids could decrease CVD risk by their anti-inflammatory anti-thrombotic function 10 A meta-analysis comprising 15806 patients showed that omega-3 fatty acids associated with a 30 reduction in fatal myocardial infarction and sudden death in addition to a 20 reduction in overall mortality 11 To the best of our knowledge no clinical trials have evaluated the effect of omega-3 supplementation on serum ACEACE2 ratio which is recently ascribed as a potential key in 2019 Covid-19 as well as CVD 59
On the other hand omega-3 fatty acids could decrease CVD risk by their anti-inflammatory anti-thrombotic function 10 A meta-analysis comprising 15806 patients showed that omega-3 fatty acids associated with a 30 reduction in fatal myocardial infarction and sudden death in addition to a 20 reduction in overall mortality 11 To the best of our knowledge no clinical trials have evaluated the effect of omega-3 supplementation on serum ACEACE2 ratio which is recently ascribed as a potential key in 2019 Covid-19 as well as CVD 59
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None