Ignite Creation Date:
2024-05-05 @ 5:19 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00436696
Status:
COMPLETED
Last Update Posted:
2018-08-07
First Post:
2007-02-15
Brief Title:
Genetic Analysis Using Blood or Bone Marrow From Participants With Neuroblastoma or Noncancerous Conditions
Sponsor:
Childrens Oncology Group
Organization:
Childrens Oncology Group
Study Overview
Official Title:
Genetic Basis of Neuroblastoma Tumorigenesis
Status:
COMPLETED
Status Verified Date:
2017-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This laboratory study is looking at genes in participants with neuroblastoma or noncancerous conditions Identifying genes related to cancer may help in the study of cancer It may also help doctors predict who is at risk of developing neuroblastoma
Detailed Description:
OBJECTIVES
I Perform a whole genome scan for association of neuroblastoma with single nucleotide polymorphisms SNP and SNP haplotypes
II Identify true disease-associated SNP alleles using a customized genotyping platform enriched for haplotype analyses in an independent sample set
III Validate disease-associated SNP alleles and haplotypes in a final independent sample set
IV Identify neuroblastoma predisposition genes
OUTLINE This is a multicenter study Participants are stratified according to presence of high-risk disease yes vs no and MYCN amplification yes vs no
DNA samples are derived from participants banked blood or uninvolved bone marrow A whole genome scan of DNA samples is employed to identify candidate single nucleotide polymorphisms SNPs The candidate SNPs are investigated using a gene-centric haplotyping approach to identify 10-20 true disease-associated alleles The disease-associated alleles are again investigated using a gene-centric haplotyping approach to validate 5-10 disease-associated SNPs SNPs are then analyzed for heritable predisposition
Patients do not receive the results of the genetic testing A certificate of confidentiality protecting the identity of research participants in this project has been issued by the Childrens Oncology Group
I Perform a whole genome scan for association of neuroblastoma with single nucleotide polymorphisms SNP and SNP haplotypes
II Identify true disease-associated SNP alleles using a customized genotyping platform enriched for haplotype analyses in an independent sample set
III Validate disease-associated SNP alleles and haplotypes in a final independent sample set
IV Identify neuroblastoma predisposition genes
OUTLINE This is a multicenter study Participants are stratified according to presence of high-risk disease yes vs no and MYCN amplification yes vs no
DNA samples are derived from participants banked blood or uninvolved bone marrow A whole genome scan of DNA samples is employed to identify candidate single nucleotide polymorphisms SNPs The candidate SNPs are investigated using a gene-centric haplotyping approach to identify 10-20 true disease-associated alleles The disease-associated alleles are again investigated using a gene-centric haplotyping approach to validate 5-10 disease-associated SNPs SNPs are then analyzed for heritable predisposition
Patients do not receive the results of the genetic testing A certificate of confidentiality protecting the identity of research participants in this project has been issued by the Childrens Oncology Group
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| ANBL06B1 | OTHER | CTEP | None |
| NCI-2009-00403 | REGISTRY | None | None |
| CDR0000522985 | None | None | None |
| COG-ANBL06B1 | None | None | None |
| ANBL06B1 | None | None | None |
| ANBL06B1 | OTHER | None | None |