Ignite Creation Date:
2024-05-05 @ 5:19 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00433303
Status:
UNKNOWN
Last Update Posted:
2007-02-09
First Post:
2007-02-08
Brief Title:
Correlation Between Coital Activity During Pregnancy and Premature Delivery Related to Prostanoid Receptor Polymorphisms
Sponsor:
Shaare Zedek Medical Center
Organization:
Shaare Zedek Medical Center
Study Overview
Official Title:
Correlation Between Coital Activity During Pregnancy and Premature Delivery Related to Prostanoid Receptor Polymorphisms
Status:
UNKNOWN
Status Verified Date:
2007-02
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of our study is correlate between premature delivery between week 23-35 of the pregnancy in women that had intercourse up to 12 hours prior to beginning of labor and polymorphisms in the gene Prostanoid receptor
Detailed Description:
During the past years there has been a conflict between different studies regarding the correlation between intercourse during pregnancy and early labor Brustman et al showed that women that were at a high risk for early delivery and had intercourse and then an early labor had significantly increase uterine activity compared to women at low risk Petridou et al showed that this risk is significantly higher at week 33 of gestation However the Cochrane Library summary leaves the question of correlation between intercourse and early labor unanswered In Sayle et als study showed no correlation between early delivery and intercourse In 2004 Oguma described 3 polymorphisms in the Prostanoid receptor gene These polymorphisms were correlated to increased activity of smooth muscles of bronchi in asthma Since this gene is also expressed in the uterine muscles we wanted to determine whether there is a correlation between the three polymorphisms T-549C C-441T T-197C G1044A and early delivery due to intercourse
1 Brustman LS Raptoulis M Langer O Anyaegbunam A Merkatz IR Changes in the pattern of uterine contractility in relationship to coitus during pregnancies at low and high risk for preterm labor Obstet Gynecol 198973166-168
2 Petridou E Salvnos H Skalkidou A Dessypris N Moustaki M Trichopoulos D Are there common triggers of preterm deliveries British J Obst Gynecol 2001108598-604
3 Kavanagh J Kelly AJ Thomas J Sexual intercourse for cervical ripening and induction of labour The Cochrane Database of Systematic Reviews 2001 Issuse 2Art NoCD003093 DOI 10100214651858CD003093
4 Sayle AE Savitz DA Thorp JM Hertz-Picciotto I Wilcox AJ Sexual activity during late pregnancy and risk of preterm delivery Obstet Gynecol 200197283-9
5 Bernal AL Mechanisms of labour-biochemical aspects BJOG 2003110Supp 2039-45
6 Oguma T Palmer L Birden E Sonna LA Asano K Lilly CM Role of prostanoid dp receptor variants in susceptibility to asthma NEJM 20043511752-63
1 Brustman LS Raptoulis M Langer O Anyaegbunam A Merkatz IR Changes in the pattern of uterine contractility in relationship to coitus during pregnancies at low and high risk for preterm labor Obstet Gynecol 198973166-168
2 Petridou E Salvnos H Skalkidou A Dessypris N Moustaki M Trichopoulos D Are there common triggers of preterm deliveries British J Obst Gynecol 2001108598-604
3 Kavanagh J Kelly AJ Thomas J Sexual intercourse for cervical ripening and induction of labour The Cochrane Database of Systematic Reviews 2001 Issuse 2Art NoCD003093 DOI 10100214651858CD003093
4 Sayle AE Savitz DA Thorp JM Hertz-Picciotto I Wilcox AJ Sexual activity during late pregnancy and risk of preterm delivery Obstet Gynecol 200197283-9
5 Bernal AL Mechanisms of labour-biochemical aspects BJOG 2003110Supp 2039-45
6 Oguma T Palmer L Birden E Sonna LA Asano K Lilly CM Role of prostanoid dp receptor variants in susceptibility to asthma NEJM 20043511752-63
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None