Ignite Creation Date:
2024-05-05 @ 5:20 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00435175
Status:
COMPLETED
Last Update Posted:
2007-02-14
First Post:
2007-02-13
Brief Title:
Acute Metabolic Effects of Estradiol
Sponsor:
University of Aarhus
Organization:
University of Aarhus
Study Overview
Official Title:
Acute Effects of Estradiol on Lipolysis in Subcutaneous Adipose Tissue and Muscle Assessed by Microdialysis and Tissue Biopsies
Status:
COMPLETED
Status Verified Date:
2007-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Estradiol promotes and maintains the typical female phenotype characterized by subcutaneous fat accumulation There is evidence to suggest that this effect relies on the ability of estradiol to increase the amount of anti-lipolytic α2A-adrenergic receptors but whether this requires long-term exposure to estradiol or is the result of an immediate effect is not clear Objective To study acute effects of a single dose 4 mg of 17β-estradiol on regional and systemic lipolysis
Detailed Description:
Estradiol affects muscle and fat distribution and thereby lipid metabolism A reduction in muscle power is seen after menopause readily counteracted by female hormone therapy HT Treatment with HT through months to previously untreated postmenopausal women or hormone replacement therapy HRT to women with Turner syndrome increases muscle mass and reduces fat mass HT in postmenopausal women furthermore prevents fat accumulation and increases lipoprotein lipase activity and lipolysis to an extent comparable to premenopausal women In contrast it has also been shown that estradiol may actually attenuate lipolysis during basal as well as catecholamine stimulated conditions In addition one study found whole body fat metabolism to be lower during treatment with estradiol than without and reduced lipolysis is present in postmenopausal women during treatment with estradiol along with an increased number of α-adrenergic receptors and a decreased number of β-adrenergic receptors
It is not clear whether the lipolytic effect of estradiol happens acutely or is dependent on chronic exposure Moreover regional differences in the pharmacodynamics of estradiol have not been assessed Finally effects on skeletal muscle have never been examined
The purpose of the present study was 1 by microdialysis to quantify the regional production of glycerol in two tissues muscle and fat and in two regions abdominal and femoral 2 To quantify the whole-body lipolytic effect of estradiol and 3 in biopsies to study intracellular mechanisms behind the action of estradiol
It is not clear whether the lipolytic effect of estradiol happens acutely or is dependent on chronic exposure Moreover regional differences in the pharmacodynamics of estradiol have not been assessed Finally effects on skeletal muscle have never been examined
The purpose of the present study was 1 by microdialysis to quantify the regional production of glycerol in two tissues muscle and fat and in two regions abdominal and femoral 2 To quantify the whole-body lipolytic effect of estradiol and 3 in biopsies to study intracellular mechanisms behind the action of estradiol
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None