Ignite Creation Date:
2024-05-05 @ 5:20 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00435708
Status:
COMPLETED
Last Update Posted:
2015-09-29
First Post:
2007-02-14
Brief Title:
Effect of Increased Fruit and Vegetable Intake on Chronic Obstructive Pulmonary Disease COPD
Sponsor:
Queens University Belfast
Organization:
Queens University Belfast
Study Overview
Official Title:
Effect of Increased Fruit and Vegetable Intake on Airway Inflammation and Oxidative Stress in Chronic Obstructive Pulmonary Disease COPD
Status:
COMPLETED
Status Verified Date:
2024-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
DISCO
Brief Summary:
Chronic obstructive pulmonary disease COPD is the UKs fastest growing fatal disease and is estimated to cost the health service close to 1 billion every year Around 80000 people in Northern Ireland suffer from COPD COPD is clinically defined as a slowly progressive condition characterised by airflow limitation which is largely irreversible Chronic inflammation and oxidative stress are key components of the underlying pathological process resulting in airflow limitation Dietary factors and nutrients that have antioxidant or anti-inflammatory properties are therefore of interest with respect to the aetiology of COPD The antioxidant vitamins C E and beta-carotene are all present in the lung milieu Such antioxidants represent the lungs first line of defence against oxygen free radicals Observational studies indicate that a low dietary intake of antioxidant nutrients or foods rich in antioxidants eg fruit and vegetables is associated with decreased lung function and increased risk of COPD To date there have been no food-based dietary interventions investigating the effect of increased fruit and vegetable intake on COPD The investigators propose to recruit people with mild to moderate COPD and low fruit and vegetable intakes 2 portions daily and randomise them to one of two study arms for 12 weeks - either to increase fruit and vegetable consumption to at least 5 portions a day or to follow their normal diet Airway and systemic oxidative stress and inflammation will be assessed at baseline and post-intervention in order to determine if fruit and vegetables have the potential to alleviate the oxidative stress and airway inflammation associated with COPD
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None