Ignite Creation Date:
2024-05-05 @ 5:21 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00431665
Status:
COMPLETED
Last Update Posted:
2007-02-06
First Post:
2007-02-05
Brief Title:
Effect of Elevated Plasma-Free-Fatty-Acids on Renal Hemodynamic Parameters
Sponsor:
Medical University of Vienna
Organization:
Medical University of Vienna
Study Overview
Official Title:
Effect of Elevated Plasma-Free-Fatty-Acids on Renal Hemodynamic Parameters
Status:
COMPLETED
Status Verified Date:
2007-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Type 2 diabetes is frequently associated with elevation of plasma-free fatty acids FFA Studies indicate that elevation of plasma-FFA induces insulin resistance and also causes endothelial dysfunction as well as hemodynamic changes which are supposed to be involved in the pathogenesis of diabetic vascular disorders
Glomerular hyperfiltration which is associated with glomerular hypertension and hypertrophy a common finding in the early course of type 1 diabetes as well as type 2 diabetes plays an important role in the development and progression of diabetic nephropathy These hemodynamic changes are not well understood but are most likely induced by dilatation of the precapillary glomerular arteriole
In humans the hemodynamic effect of FFAs has so far been investigated locally in brachial and femoral arteries and recently in the eye and skin where FFAs induced a pronounced increase in blood flow probably due to a local decrease in vascular resistance
The aim of the present study is to characterise the hemodynamic effects of FFAs in the kidney In addition we want to test the hypothesis that FFA-induced changes are mediated via endothelial derived nitric oxide NO The results of this study could provide information to what extent elevated FFA-plasma levels contribute to hyperfiltration in the early course of diabetes mellitus The measurements will be done at baseline and during 4 hour infusion of a triglyceride or placebo infusion combined with heparin
Glomerular hyperfiltration which is associated with glomerular hypertension and hypertrophy a common finding in the early course of type 1 diabetes as well as type 2 diabetes plays an important role in the development and progression of diabetic nephropathy These hemodynamic changes are not well understood but are most likely induced by dilatation of the precapillary glomerular arteriole
In humans the hemodynamic effect of FFAs has so far been investigated locally in brachial and femoral arteries and recently in the eye and skin where FFAs induced a pronounced increase in blood flow probably due to a local decrease in vascular resistance
The aim of the present study is to characterise the hemodynamic effects of FFAs in the kidney In addition we want to test the hypothesis that FFA-induced changes are mediated via endothelial derived nitric oxide NO The results of this study could provide information to what extent elevated FFA-plasma levels contribute to hyperfiltration in the early course of diabetes mellitus The measurements will be done at baseline and during 4 hour infusion of a triglyceride or placebo infusion combined with heparin
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None