Ignite Creation Date:
2024-05-06 @ 3:59 PM
Last Modification Date:
2024-10-26 @ 2:01 PM
Study NCT ID:
NCT04837027
Status:
COMPLETED
Last Update Posted:
2022-10-12
First Post:
2021-04-06
Brief Title:
Effect of Training on Brain Volume in Ataxia
Sponsor:
Columbia University
Organization:
Columbia University
Study Overview
Official Title:
Balance Versus Aerobic Training in Degenerative Cerebellar Diseases
Status:
COMPLETED
Status Verified Date:
2022-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The primary aim is to show balance training improves DCD individuals ability to compensate for their activity limitations but does not impact disease progression
The second aim is to demonstrate aerobic exercise improves balance and gait in DCD persons by affecting brain processes and slowing cerebellar atrophy
The second aim is to demonstrate aerobic exercise improves balance and gait in DCD persons by affecting brain processes and slowing cerebellar atrophy
Detailed Description:
Individuals with degenerative cerebellar disease DCD exhibit gradual loss of coordination resulting in impaired balance gait deviations and severe progressive disability With no available disease-modifying medications balance training is the primary treatment option to improve motor skills and functional performance There is no evidence however that balance training impacts DCD at the tissue level
Aerobic training on the other hand may modify DCD progression as evident from animal data Compared to sedentary controls aerobically trained DCD rats have enhanced lifespan motor function and cerebellar Purkinje cell survival Numerous animal studies also document that aerobic training has a direct favorable effect on the brain that includes production of neurotrophic hormones enhancement of neuroplasticity mechanisms and protection from neurotoxins
The effects of aerobic training in humans with DCD are relatively unknown despite these encouraging animal data A single study to date has evaluated the benefits of aerobic exercise on DCD in humans and this was a secondary outcome of the study Although participants performed limited aerobic training during the study modest functional benefits were still detected
The main objective of this project will be to compare the benefits of aerobic versus balance training in DCD We hypothesize that both aerobic and balance training will improve function in DCD subjects but that the mechanisms in which these improvements occur differ 1 Balance training improves DCD individuals ability to compensate for their activity limitations but does not impact disease progression 2 Aerobic exercise improves balance and gait in DCD persons by impacting the cerebellum
Aerobic training on the other hand may modify DCD progression as evident from animal data Compared to sedentary controls aerobically trained DCD rats have enhanced lifespan motor function and cerebellar Purkinje cell survival Numerous animal studies also document that aerobic training has a direct favorable effect on the brain that includes production of neurotrophic hormones enhancement of neuroplasticity mechanisms and protection from neurotoxins
The effects of aerobic training in humans with DCD are relatively unknown despite these encouraging animal data A single study to date has evaluated the benefits of aerobic exercise on DCD in humans and this was a secondary outcome of the study Although participants performed limited aerobic training during the study modest functional benefits were still detected
The main objective of this project will be to compare the benefits of aerobic versus balance training in DCD We hypothesize that both aerobic and balance training will improve function in DCD subjects but that the mechanisms in which these improvements occur differ 1 Balance training improves DCD individuals ability to compensate for their activity limitations but does not impact disease progression 2 Aerobic exercise improves balance and gait in DCD persons by impacting the cerebellum
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None