Ignite Creation Date:
2024-05-05 @ 5:21 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00430690
Status:
COMPLETED
Last Update Posted:
2019-08-07
First Post:
2007-02-01
Brief Title:
Acoustic Startle Reduction In Cocaine Dependence
Sponsor:
Emory University
Organization:
Emory University
Study Overview
Official Title:
Acoustic Startle Reduction In Cocaine Dependence
Status:
COMPLETED
Status Verified Date:
2019-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Chronic cocaine administration leads to changes in brain function that persist long after the acute withdrawal phase The acoustic startle response ASR is a well characterized reflexive response to a sudden acoustic stimulus The ASR is mediated by a simple 3-synapse subcortical circuit it is modulated in part by brain areas and neurotransmitters associated with cocaine administration Our initial study and subsequent replication reveals a profound diminution of the ASR in cocaine-dependent subjects after a brief period of abstinence Our preliminary findings indicate that first degree relatives of cocaine-dependent subjects also have reduced startle compared to healthy controls The findings of low ASR in rats and humans during cocaine washout and low ASR in family members suggests there may be both a trait and state component of the startle reductions we have reported
The central objectives of this proposal are to dissect this finding with regard to its development and persistence in early and later phases of cocaine abstinence in humans to ascertain whether startle reduction and its potential normalization during later abstinence is a predictor of clinical course in human subjects with cocaine dependence and to examine whether startle reduction is at least in part a vulnerability trait for the development of cocaine dependence This latter Aim will be carried out in humans by testing siblings of cocaine-dependent subjects
Cocaine dependence is an enormous public health problem The significance of this work lies in the potential for the ASR reduction to serve as a reliable easily repeatable biological measure of cocaine-induced brain changes that may enhance outcome prediction so that tailored treatments may be directed at those patients most vulnerable to relapse given the restriction of resources for available for substance abuse treatment
The central objectives of this proposal are to dissect this finding with regard to its development and persistence in early and later phases of cocaine abstinence in humans to ascertain whether startle reduction and its potential normalization during later abstinence is a predictor of clinical course in human subjects with cocaine dependence and to examine whether startle reduction is at least in part a vulnerability trait for the development of cocaine dependence This latter Aim will be carried out in humans by testing siblings of cocaine-dependent subjects
Cocaine dependence is an enormous public health problem The significance of this work lies in the potential for the ASR reduction to serve as a reliable easily repeatable biological measure of cocaine-induced brain changes that may enhance outcome prediction so that tailored treatments may be directed at those patients most vulnerable to relapse given the restriction of resources for available for substance abuse treatment
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01DA018294-01A2 | NIH | None | httpsreporternihgovquickSearchR01DA018294-01A2 |