Ignite Creation Date:
2024-05-05 @ 5:21 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00434915
Status:
COMPLETED
Last Update Posted:
2011-03-23
First Post:
2007-02-12
Brief Title:
Does DHEA Enhance the Effects of Exercise in Postmenopausal Women
Sponsor:
Mayo Clinic
Organization:
Mayo Clinic
Study Overview
Official Title:
Does DHEA Enhance the Effects of Exercise in Postmenopausal Women
Status:
COMPLETED
Status Verified Date:
2011-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Dehydroepiandrostrone DHEA and its sulfated ester DHEAS are high circulating weak androgens which have been associated with conditions that accompany age-related decline such as sarcopenia hyperinsulinemia osteopenia and cardiovascular disease The decline in DHEA with age is particularly marked in postmenopausal women Exercise has always been advocated in women benefit has been demonstrated inmuscle bone and lipid physiology as well as perception of energy and sense of well-being This study aims to explore the combined effect of both DHEA and exercise in postmenopausal women age range 55-75 years old Subjects will receive DHEA 50mgday or placebo for a 12-week period At the beginning and conclusion of the study patients will undergo testing for muscle strength body composition VO2 max insulin sensitivity muscle biopsy with mitochondria enzyme measurements and psychological analysis Blood samples pre and post intervention will also be obtained and the level of selected anabolic markers lipids and androgenic and sex steroid levels will be assessed For the twelve-week period both placebo and DHEA treated participants will be involved in a resistance and aerobic exercise program coordinated through the GCRC and the Dan Abraham Healthy Living Center Several correlations have been established with respect to exogenous DHEA administration in postmenopausal women None have evaluated oral DHEA therapy in the setting resistance and aerobic exercise key therapies advocated in postmenopausal women As a plausible anabolic hormone DHEA is hypothesized to accentuate the effects of exercise as has been shown for testosterone This study as a randomized double-blind placebo controlled trial will investigate the effects if any of a regimented exercise program and DHEA supplementation in postmenopausal women specifically for evidence of enhancement of exercise effect by oral supplementation with DHEA in attenuating age-related decline
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| P01AG014383 | NIH | None | httpsreporternihgovquickSearchP01AG014383 |