Ignite Creation Date:
2024-05-05 @ 5:21 PM
Last Modification Date:
2024-10-26 @ 9:30 AM
Study NCT ID:
NCT00431392
Status:
COMPLETED
Last Update Posted:
2007-02-05
First Post:
2007-02-02
Brief Title:
Mechanisms of Choroidal Blood Flow Changes During DarkLight Transitions
Sponsor:
Medical University of Vienna
Organization:
Medical University of Vienna
Study Overview
Official Title:
Mechanisms of Choroidal Blood Flow Changes During DarkLight Transitions
Status:
COMPLETED
Status Verified Date:
2007-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
There is evidence from a variety of animal studies that choroidal blood flow is under neural control By contrast only little information is available from human studies Recent results indicate that a lightdark transition is associated with a short lasting reduction in choroidal blood flow We have shown that during unilateral darklight transition both eyes react with choroidal vasoconstriction strongly indicating a neural mechanism
The present studies investigate this possibility by using pharmacological interventions The pharmacological agents tested include a nitric oxide synthase inhibitor an alpha-receptor agonist as a control substance for the blood pressure increasing nitric oxide synthase inhibitor a muscarinic receptor blocker and a non-specific beta-blocker These drugs were chosen on the basis of previous animal experiments as the systems which are specifically influenced by these substances are likely involved in neural control of choroidal blood flow
The present studies investigate this possibility by using pharmacological interventions The pharmacological agents tested include a nitric oxide synthase inhibitor an alpha-receptor agonist as a control substance for the blood pressure increasing nitric oxide synthase inhibitor a muscarinic receptor blocker and a non-specific beta-blocker These drugs were chosen on the basis of previous animal experiments as the systems which are specifically influenced by these substances are likely involved in neural control of choroidal blood flow
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None