Ignite Creation Date:
2024-05-05 @ 5:22 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00442884
Status:
COMPLETED
Last Update Posted:
2007-03-05
First Post:
2007-03-02
Brief Title:
Effect of Acute Psychological Stress on Glucose Concentrations in Patients With Type 2 Diabetes
Sponsor:
University of Zurich
Organization:
University of Zurich
Study Overview
Official Title:
Effect of Acute Psychological Stress on Glucose Concentrations in Patients With Type 2 Diabetes
Status:
COMPLETED
Status Verified Date:
2007-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The study is designed to evaluate the effects of acute psychological stress on blood glucose levels We will study one group of patients in the fasting state on a control day and a stress test day another group will undergo the same protocol in the postprandial state
Detailed Description:
Patients with type 2 diabetes often complain about changing blood glucose levels in times of emotional or mental stress most subjects self-reporting higher blood glucose measurements in stressful conditions To daily distress in diabetes additional emotional or mental stress can add a further momentum to destabilize glucose levels due to the adrenocortical response with enhancing insulin resistance and decreasing the endogenous insulin secretion Another physiological link between stress and diabetes might be a higher sensitivity of the hypothalamo-pituitary-adrenal axis leading to antagonizing effects on insulin actions A study in type 2 diabetes demonstrated that stressors can destabilize blood glucose levels Stress levels in diabetes have been shown to have a relationship to diabetic complications Previous studies of psychological stress in type 1 diabetes have shown no effect of elevated catecholamine levels after short-lived psychological stimuli on glucose levels but a significantly delayed decrease of glucose concentrations after an acute psychological stress in the postprandial state in association with elevated cortisol levels showing no change of glucose concentration in the fasting state This was in contrast to previous data in healthy subjects showing that low glucose levels before a psychological stress prevented the stress-induced activation of the hypothalamus pituitary adrenal axis but postprandial higher blood glucose levels induced a large cortisol response These findings of a different cortisol responses in the fasting or fed status in healthy or absolute insulin deficient subjects could also be relevant for glucose metabolism in subjects with type 2 diabetes
The effect of an acute psychological stress on glucose concentration may critically depend on whether stress is applied in the fasting or fed state A different metabolic response to stress depending on food intake could explain different findings in other clinical trials and contribute to understanding glucose responses to stress The aim of our study was thus to test whether the effect of acute psychological stress on glucose concentrations is different in the fasting compared to the fed state in type 2 diabetes
The effect of an acute psychological stress on glucose concentration may critically depend on whether stress is applied in the fasting or fed state A different metabolic response to stress depending on food intake could explain different findings in other clinical trials and contribute to understanding glucose responses to stress The aim of our study was thus to test whether the effect of acute psychological stress on glucose concentrations is different in the fasting compared to the fed state in type 2 diabetes
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None