Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005528
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Genetics of CVD Risk Factors in Samoans
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To evaluate the role of known genes involved in lipid metabolism on serum lipid and apolipoprotein levels in Samoans residing in American and Western Samoa who were exposed to the biobehavioral changes of modernization
Detailed Description:
BACKGROUND
Modernizing Samoans are characterized by high levels of certain cardiovascular disease CVD risk factors such as extreme adiposity and high prevalences of obesity and hypertension However lipid levels in Samoans such as total cholesterol and high density lipoprotein HDL cholesterol are not consistent with their obesity and not always consistent with ecological measures of modernization
DESIGN NARRATIVE
The cross-sectional study used serum lipid and lipoprotein and dietary data collected in 1994 and 1995 in American and Western Samoa to compare the American and Western Samoans Quantitative determinations were made of lipid and apolipoprotein levels differences between the two groups Estimates were made of the effects of dietary intake body size and smoking on lipid and apolipoproteins Cross-sectional analyses were performed on genetic factors influencing lipid and lipoprotein levels Statistical analyses were conducted to test hypotheses about gene-environment interactions and gene-gene interactions in polynesians from American Samoa and Western Samoa
Diet physical activity and body size vary with exposure to the influences of economic modernization and the adoption of non-traditional behaviors Although adiposity and its central distribution insulin blood pressure and dietary cholesterol increase from Western Samoa to American Samoa saturated fat intakes due to coconuts and cigarette smoking are greater in Western Samoa Thus modernization does not produce simple unilineal changes in risk factors The investigators examined very specific hypotheses based on the cross-sectional data collected in 1994 and 1995 about the influence of genes on lipids about genetic interactions on lipids and about concrete environmental and specific gene interactions on lipid outcomes
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Modernizing Samoans are characterized by high levels of certain cardiovascular disease CVD risk factors such as extreme adiposity and high prevalences of obesity and hypertension However lipid levels in Samoans such as total cholesterol and high density lipoprotein HDL cholesterol are not consistent with their obesity and not always consistent with ecological measures of modernization
DESIGN NARRATIVE
The cross-sectional study used serum lipid and lipoprotein and dietary data collected in 1994 and 1995 in American and Western Samoa to compare the American and Western Samoans Quantitative determinations were made of lipid and apolipoprotein levels differences between the two groups Estimates were made of the effects of dietary intake body size and smoking on lipid and apolipoproteins Cross-sectional analyses were performed on genetic factors influencing lipid and lipoprotein levels Statistical analyses were conducted to test hypotheses about gene-environment interactions and gene-gene interactions in polynesians from American Samoa and Western Samoa
Diet physical activity and body size vary with exposure to the influences of economic modernization and the adoption of non-traditional behaviors Although adiposity and its central distribution insulin blood pressure and dietary cholesterol increase from Western Samoa to American Samoa saturated fat intakes due to coconuts and cigarette smoking are greater in Western Samoa Thus modernization does not produce simple unilineal changes in risk factors The investigators examined very specific hypotheses based on the cross-sectional data collected in 1994 and 1995 about the influence of genes on lipids about genetic interactions on lipids and about concrete environmental and specific gene interactions on lipid outcomes
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL052611 | NIH | None | httpsreporternihgovquickSearchR01HL052611 |