Ignite Creation Date:
2024-05-05 @ 5:23 PM
Last Modification Date:
2024-10-26 @ 9:31 AM
Study NCT ID:
NCT00441779
Status:
TERMINATED
Last Update Posted:
2016-07-12
First Post:
2007-02-28
Brief Title:
Transfusion-Associated Microchimerism in Previously Injured Individuals Who Received a Blood Transfusion
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
Retrospective Study of the Prevalence of Transfusion-Associated Microchimerism Following Traumatic Injury Burns and Elective Orthopedic Procedures
Status:
TERMINATED
Status Verified Date:
2014-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
A separate study similar subjects identified transfusion-associated microchimerism only rarely making this observational study impractical to conduct
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Blood transfusions are frequently necessary in situations in which there is a large amount of blood loss In some individuals who receive a blood transfusion white blood cells from the donors blood may remain in the body for years a condition known as microchimerism This study will evaluate the occurrence of microchimerism among the following three groups of individuals who previously received transfusions 1 individuals with traumatic injuries 2 individuals with burn injuries and 3 individuals who underwent elective orthopedic operations
Detailed Description:
Approximately 10 to 15 of injured patients who receive blood transfusions experience a condition known as transfusion-associated microchimerism This occurs when white blood cells or leukocytes from the donors blood persist in the recipient long after the transfusion occurs The genetically distinct donor cells can remain in the individual for decades and may account for as many as 4 of the white blood cells in the recipients body This suggests that the donor cells are tolerated by the recipients immune system The purpose of this study is to compare the incidence of microchimerism among individuals with three different types of injuries 1 traumatic injuries 2 thermal or burn injuries and 3 injuries resulting from elective orthopedic surgical procedures
In this study blood samples will be collected from individuals who were treated for traumatic injury thermal injury or elective orthopedic surgical procedures at the University of California at Davis Medical Center Individuals who were treated from 2000 to 2003 and received a blood transfusion as well as a control group of individuals who did not receive a transfusion will be approached to enroll in the study Individuals who agree to participate will have their blood analyzed for evidence of microchimerism Information on health status injury characteristics hospital care blood transfusion details and blood donor characteristics will be collected from all participants
In this study blood samples will be collected from individuals who were treated for traumatic injury thermal injury or elective orthopedic surgical procedures at the University of California at Davis Medical Center Individuals who were treated from 2000 to 2003 and received a blood transfusion as well as a control group of individuals who did not receive a transfusion will be approached to enroll in the study Individuals who agree to participate will have their blood analyzed for evidence of microchimerism Information on health status injury characteristics hospital care blood transfusion details and blood donor characteristics will be collected from all participants
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 1R01HL083388 | NIH | None | httpsreporternihgovquickSearch1R01HL083388 |