Ignite Creation Date:
2024-05-05 @ 9:42 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005239
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Genetic Epidemiology of Coronary Heart Disease Risk in Women Twins
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To examine genetic and environmental influences on several recently identified coronary heart disease risk factors in identical and fraternal adult women twins The risk factors included low density lipoprotein LDL subclass patterns plasma apolipoprotein levels body fat distribution and serum insulin levels
Detailed Description:
BACKGROUND
In 1974 a twin registry was established from members of the Kaiser Permanente Medical Care Programs Northern California region In all 9821 twin pairs were enrolled In 1978-1979 434 pairs of female twins were recruited from the registry for a clinical examination of coronary heart disease risk factors The clinical examination included an extensive health questionnaire measurements of plasma lipids and serum chemistries analyses of genetic markers for determination of zygosity measurement of expired air carbon monoxide and serum thiocyanate levels and a complete physical examination During the ten years since the first examination several new or more specific coronary heart disease risk factors have been recognized including low density lipoprotein and insulin levels and the anatomic distribution of body fat
DESIGN NARRATIVE
All women who participated in the first examination were invited to participate in the second examination Medical records andor death certificates were obtained to document coronary heart disease events Questionnaires were used to collect information on health history nutrition and physical activity A clinical examination assessed blood pressure a variety of anthropometric measures and cardiovascular fitness Blood specimens were collected for clinical chemistry and lipidlipoprotein profiles To assess genetic influence the heritability of each of the risk factors was estimated Blood was frozen for future studies of polymorphic DNA markers Using the monozygotic co-twin control method the effects of environmental or behavioral factors on these risk factors were assessed after controlling for genetic factors that could explain their association Two hypotheses were examined that could be uniquely addressed using twin data First the association of body fat distribution with other coronary heart disease risk factors was mediated by serum insulin levels Secondly cardiovascular fitness explained in part the association of physical activity with coronary heart disease risk factors such as HDL-cholesterol and insulin levels Lipoprotein analyses were conducted at Donner Laboratory at Berkeley
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
In 1974 a twin registry was established from members of the Kaiser Permanente Medical Care Programs Northern California region In all 9821 twin pairs were enrolled In 1978-1979 434 pairs of female twins were recruited from the registry for a clinical examination of coronary heart disease risk factors The clinical examination included an extensive health questionnaire measurements of plasma lipids and serum chemistries analyses of genetic markers for determination of zygosity measurement of expired air carbon monoxide and serum thiocyanate levels and a complete physical examination During the ten years since the first examination several new or more specific coronary heart disease risk factors have been recognized including low density lipoprotein and insulin levels and the anatomic distribution of body fat
DESIGN NARRATIVE
All women who participated in the first examination were invited to participate in the second examination Medical records andor death certificates were obtained to document coronary heart disease events Questionnaires were used to collect information on health history nutrition and physical activity A clinical examination assessed blood pressure a variety of anthropometric measures and cardiovascular fitness Blood specimens were collected for clinical chemistry and lipidlipoprotein profiles To assess genetic influence the heritability of each of the risk factors was estimated Blood was frozen for future studies of polymorphic DNA markers Using the monozygotic co-twin control method the effects of environmental or behavioral factors on these risk factors were assessed after controlling for genetic factors that could explain their association Two hypotheses were examined that could be uniquely addressed using twin data First the association of body fat distribution with other coronary heart disease risk factors was mediated by serum insulin levels Secondly cardiovascular fitness explained in part the association of physical activity with coronary heart disease risk factors such as HDL-cholesterol and insulin levels Lipoprotein analyses were conducted at Donner Laboratory at Berkeley
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL041830 | NIH | None | httpsreporternihgovquickSearchR01HL041830 |