Ignite Creation Date:
2024-05-06 @ 4:27 PM
Last Modification Date:
2024-10-26 @ 2:10 PM
Study NCT ID:
NCT04986384
Status:
COMPLETED
Last Update Posted:
2021-08-02
First Post:
2021-05-29
Brief Title:
Effect of a Topical Spray on Itch Relief in Moderate-to-severe Childhood Eczema
Sponsor:
Prof HON Kam Lun Ellis
Organization:
Chinese University of Hong Kong
Study Overview
Official Title:
Effect of a Topical Spray on Itch Relief in Moderate-to-severe Childhood Eczema
Status:
COMPLETED
Status Verified Date:
2021-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Pruritus is defined as an unpleasant sensation of the skin that provoke the desire to scratch or rub Its presence is an essential diagnostic feature According to some European studies 91 of patients with Atopic Dermatitis report suffering from pruritus at least once daily And 581 of them experience chronic pruritus leading to great deterioration in quality of life Various internal and external factors may trigger pruritus Mediators secretion such as keratinocyte-derived Thymic Stromal Lymphopoietin TSLP and Nerve Growth Factor NGF could activate nerve fibres which will eventually transmit signals to the brain causing the sensation of itching
Although being one of the major annoying symptoms faced by patients with Atopic Dermatitis effective anti-itching treatments are not available There is no consistent evidence that topical antihistamines can relief itch
Recently a new spray named Atoderm SOS is developed The skin relief technology by ambora extract and Epigallocatechin gallate EGCG associated to enoxolone claimed to inhibit the release TSLP and NGF which eventually could reduce nerve signals to the brain for itchy feelings Therefore our group would like to test the efficacy of this proprietary anti-itch product with our paediatric patients using a wait-list approach as a control It is aimed to demonstrate that the using the Atoderm SOS spray topically whenever necessary can reduce the unpleasant itchy Atopic Dermatitiss symptom improve quality of life as well as to reduce the need for topical treatment
Although being one of the major annoying symptoms faced by patients with Atopic Dermatitis effective anti-itching treatments are not available There is no consistent evidence that topical antihistamines can relief itch
Recently a new spray named Atoderm SOS is developed The skin relief technology by ambora extract and Epigallocatechin gallate EGCG associated to enoxolone claimed to inhibit the release TSLP and NGF which eventually could reduce nerve signals to the brain for itchy feelings Therefore our group would like to test the efficacy of this proprietary anti-itch product with our paediatric patients using a wait-list approach as a control It is aimed to demonstrate that the using the Atoderm SOS spray topically whenever necessary can reduce the unpleasant itchy Atopic Dermatitiss symptom improve quality of life as well as to reduce the need for topical treatment
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None