Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:01 AM
Study NCT ID:
NCT00000497
Status:
COMPLETED
Last Update Posted:
2015-04-15
First Post:
1999-10-27
Brief Title:
Dietary Intervention Study for Hypertension DISH
Sponsor:
University of Mississippi Medical Center
Organization:
University of Mississippi Medical Center
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The primary objective of this multicenter cooperative clinical trial was to determine if dietary modification would enable drug controlled hypertensive patients to remain at goal blood pressures after antihypertensive medication was withdrawn The proposal made use of the HDFP hypertensive population who had five years of treatment for their hypertension Additionally the group of investigators proposed to determine if dietary treatment would permit patients not previously adequately controlled under the HDFP program to achieve normalization of blood pressure with a combination of dietary modification and drug treatment The study also proposed to search for predictors ie levels of hormonal agents such as plasma renin activity of responsiveness to dietary manipulation among the hypertensive population as well as to identify psychological attributes that might be of importance in managing these patients
Detailed Description:
BACKGROUND
The background against which the proposal was made had been developed from the combined information of the Veterans Administration Cooperative Study and the Hypertension Detection and Follow-up Study Data from both these studies clearly established the importance of reducing sodium content by means of diuretic administration as a mainstay of the treatment of elevated blood pressure The risks of the lifetime of treatment were undefined but the cost of indefinite treatment of high blood pressure was sufficiently high to stimulate careful examination of alternative modes of management of such patients The demonstrations by Parijs and others that moderate reduction in sodium intake led to improved management of hypertension and data suggesting that increased potassium intake may enhance this blood pressure lowering effect associated with sodium restriction was cited by the investigators as a basis for the trial Any additional data regarding modest sodium restriction and potassium ingestion would have impact on utilizing such therapy in preventing hypertension and as adjunctive therapy
DESIGN NARRATIVE
The study was intended to take advantage of the availability of patients at the three centers at the completion of the Hypertension Detection and Follow-up Program Study These patients were enrolled as stepped-care participants and had been treated with antihypertensive drugs for at least five years The main objective of the study was to determine the contribution of dietary modification to maintenance of normal blood pressure after withdrawal of medication Two types of diet change were followed 1 reduction of sodium intake coupled with increased potassium intake and 2 reduction of weight in the subgroups of patients that were obese
The background against which the proposal was made had been developed from the combined information of the Veterans Administration Cooperative Study and the Hypertension Detection and Follow-up Study Data from both these studies clearly established the importance of reducing sodium content by means of diuretic administration as a mainstay of the treatment of elevated blood pressure The risks of the lifetime of treatment were undefined but the cost of indefinite treatment of high blood pressure was sufficiently high to stimulate careful examination of alternative modes of management of such patients The demonstrations by Parijs and others that moderate reduction in sodium intake led to improved management of hypertension and data suggesting that increased potassium intake may enhance this blood pressure lowering effect associated with sodium restriction was cited by the investigators as a basis for the trial Any additional data regarding modest sodium restriction and potassium ingestion would have impact on utilizing such therapy in preventing hypertension and as adjunctive therapy
DESIGN NARRATIVE
The study was intended to take advantage of the availability of patients at the three centers at the completion of the Hypertension Detection and Follow-up Program Study These patients were enrolled as stepped-care participants and had been treated with antihypertensive drugs for at least five years The main objective of the study was to determine the contribution of dietary modification to maintenance of normal blood pressure after withdrawal of medication Two types of diet change were followed 1 reduction of sodium intake coupled with increased potassium intake and 2 reduction of weight in the subgroups of patients that were obese
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U01HL037854 | NIH | None | httpsreporternihgovquickSearchU01HL037854 |