Ignite Creation Date:
2024-05-06 @ 4:34 PM
Last Modification Date:
2024-10-26 @ 2:12 PM
Study NCT ID:
NCT05021783
Status:
COMPLETED
Last Update Posted:
2021-08-26
First Post:
2021-08-16
Brief Title:
The Relationship Between Magnetic Resonance Imaging MRI Scores and Sensory Testing in Axial Spondyloarthritis
Sponsor:
Marmara University
Organization:
Marmara University
Study Overview
Official Title:
Investigation of the Relationship Between Sacroiliac Magnetic Resonance Imaging MRI Scores and Quantitative Sensory Testing in Patients With Axial Spondyloarthritis
Status:
COMPLETED
Status Verified Date:
2021-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Axial spondyloarthritis is one of the most common rheumatic diseases and chronic pain and morning stiffness are the main complaints of these patients Central sensitization is defined as increased response to normal or sub-threshold stimuli of central nervous system and its close relationship with many rheumatological diseases has been demonstrated in several studies There is no method for the diagnosis of central sensitization is accepted as a gold standard The clinical scales and quantitative sensory testing QST widely is used for this purpose widely The most commonly used QST types include pressure pain threshold PPT temporal summation TS and conditioned pain modulation CPM The well-known scale used for the evaluation of central sensitization is the Central Sensitization Inventory CSI developed in 2011 for detect central sensitization in chronic pain patients In this study it was aimed to investigate the relationship between QST and CSI and sacroiliac MRI changes
Detailed Description:
Central sensitization is hypersensitivity and increased response to normalpainless stimuli due to dysfunction in endogenous pain pathways Quantitative sensory testing is frequently used to detect pain sensitization and pressure pain threshold PPT and temporal summation TS are often preferred for this purpose Recently in addition to these methods conditional pain modulation CPM in which descending pain pathways are tested is also preferred With PPT and TS measurement localgeneralized sensitivity increase can be detected in patients who develop pain sensitization Observation of increased nociceptor response and decrease in pressure pain threshold in the tissue damaged area is interpreted in favor of peripheral sensitization while obtaining a similar response in adjacent or distant areas is defined as generalized increased sensitivity Although it is known that local hyperalgesia is one of the main findings of inflammation studies that have shown this quantitatively are limited Inflammatory lesions are observed in patients with axial spondyloarthritis especially in the active stages of the disease and the relationship of these lesions with PPT TS and CPM values and pain sensitization is unknown Therefore in this study it was planned to investigate the relationship of inflammatory and structural lesions detected by sacroiliac MRI with regional PPTTS CPM and pain sensitization in patients diagnosed with axSpA
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None