Ignite Creation Date:
2024-05-05 @ 5:28 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00460044
Status:
COMPLETED
Last Update Posted:
2007-04-13
First Post:
2007-04-11
Brief Title:
ADMA and Mechanical Ventilation in Preterm Infants
Sponsor:
Amsterdam UMC location VUmc
Organization:
Amsterdam UMC location VUmc
Study Overview
Official Title:
Plasma ADMA Concentrations at Birth and Mechanical Ventilation in Preterm Infants
Status:
COMPLETED
Status Verified Date:
2007-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to study the relation between mechanical ventilation and ADMA concentrations at birth
Detailed Description:
Nitric oxide NO plays an important role in the normal development and maturation of the lungs In addition NO is an important mediator of vascular smooth muscle relaxation ventilation perfusion matching neurotransmission and host defence and bacteriostasis Asymmetric dimethylarginine ADMA is an endogenous derivative of arginine that inhibits NOS and thereby the bioavailability of NO Preterm infants have increased concentrations of ADMA Therefore inhibition of NO by increased concentrations of ADMA which could be associated with reduced pulmonary functioning
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None