Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001551
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
1999-11-03
Brief Title:
Characteristics of Idiopathic Familial Speech Disorders
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Characteristics of Idiopathic Familial Speech Disorders
Status:
COMPLETED
Status Verified Date:
2009-11-13
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
According to studies speech disorders with unknown causes idiopathic affect approximately 5 of the population at some point in their life Some of these disorders like stuttering and cluttering are known for being detected early during speech development
Stuttering is characterized by sound and syllable repetitions and consonantvowel prolongations When stuttering is moderate to severe it can interfere with a persons job and social activities
Speech articulation disorders are characterized by omissions or substitutions of speech sounds The speech of a person who clutters is often difficult to understand People are often unaware of the errors they make when speaking causing treatment of the condition to be very difficult
The purpose of this research is to study an extended family whose members exhibit a pure form of speech articulation disorders
In addition the study will use data and information gathered from the study and use it to develop guidelines criteria for defining and differentiating patients with speech disorders
Stuttering is characterized by sound and syllable repetitions and consonantvowel prolongations When stuttering is moderate to severe it can interfere with a persons job and social activities
Speech articulation disorders are characterized by omissions or substitutions of speech sounds The speech of a person who clutters is often difficult to understand People are often unaware of the errors they make when speaking causing treatment of the condition to be very difficult
The purpose of this research is to study an extended family whose members exhibit a pure form of speech articulation disorders
In addition the study will use data and information gathered from the study and use it to develop guidelines criteria for defining and differentiating patients with speech disorders
Detailed Description:
Objective
Our objective is to determine which factors are involved in the development of stuttering and familial phonological processing disorder and are associated with a familial pattern of inheritance
Study population The study population is comprised of 8 groups
1 Children and adults with persistent developmental stuttering
2 Unaffected siblings of the individuals affected with developmental stuttering or recovered from stuttering
3 Children and adults who have recovered from developmental stuttering
4 Children and adults with persistent familial phonological processing disorders FPPD
5 Unaffected siblings of the individuals affected with FPPD or have recovered from FPPD
6 Children and adults who have recovered from FPPD
7 Unaffected siblings of the individuals who have recovered from FPPD
8 Children and adults with normal speech and language development who will comprise the control groups
Design A Natural history design will be used to compare affected and unaffected family members with healthy volunteers with normal speech and language
Outcome Measures Genetic markers and pedigree analyses will be used to test familial inheritance patterns Speech and language development will be compared using indices of speech perception auditory perception self monitoring of ones own speech language complexity motor complexity speech learning phonological processing and verbalnonverbal memory
Our objective is to determine which factors are involved in the development of stuttering and familial phonological processing disorder and are associated with a familial pattern of inheritance
Study population The study population is comprised of 8 groups
1 Children and adults with persistent developmental stuttering
2 Unaffected siblings of the individuals affected with developmental stuttering or recovered from stuttering
3 Children and adults who have recovered from developmental stuttering
4 Children and adults with persistent familial phonological processing disorders FPPD
5 Unaffected siblings of the individuals affected with FPPD or have recovered from FPPD
6 Children and adults who have recovered from FPPD
7 Unaffected siblings of the individuals who have recovered from FPPD
8 Children and adults with normal speech and language development who will comprise the control groups
Design A Natural history design will be used to compare affected and unaffected family members with healthy volunteers with normal speech and language
Outcome Measures Genetic markers and pedigree analyses will be used to test familial inheritance patterns Speech and language development will be compared using indices of speech perception auditory perception self monitoring of ones own speech language complexity motor complexity speech learning phonological processing and verbalnonverbal memory
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 96-N-0088 | None | None | None |