Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005512
Status:
COMPLETED
Last Update Posted:
2016-03-01
First Post:
2000-05-25
Brief Title:
Genetic Epidemiology--Development of Cardiovascular Risk
Sponsor:
Virginia Commonwealth University
Organization:
Virginia Commonwealth University
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2016-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine how genetic and environmental factors influence the co-occurrence of obesity and hypertension during development and to identify cardiovascular risk factors in adolescence that will predict cardiovascular disease in adults
Detailed Description:
BACKGROUND
Obesity and hypertension are two of the major risk factors for cardiovascular disease CVD and those with obesity have a greater risk of hypertension In children and adolescents high body mass index correlates with elevated blood pressure Genetic factors make a significant contribution to the variation of obesity and hypertension
DESIGN NARRATIVE
Anthropometric cardiovascular physiologic and physical fitness data were used to investigate a series of critical issues about the etiology heterogeneity comorbidity and developmental trajectories of CVD risk factors including obesity hypertension and cardiovascular health Using the two datasets the main questions of the study were addressed How do genes and environment act and interact to create covariation between obesity and hypertension and were the genetic and environmental factors the same at all ages from childhood to late adolescence and adulthood in both sexes Areas of research included the following causes of individual differences in anthropometric and cardiovascular characteristics their covariation and developmental change or continuity in adolescence parent-offspring transmission prediction of cardiovascular risk and sex race and population differences in genetic and environmental contributions on cardiovascular risk factors
Obesity and hypertension are two of the major risk factors for cardiovascular disease CVD and those with obesity have a greater risk of hypertension In children and adolescents high body mass index correlates with elevated blood pressure Genetic factors make a significant contribution to the variation of obesity and hypertension
DESIGN NARRATIVE
Anthropometric cardiovascular physiologic and physical fitness data were used to investigate a series of critical issues about the etiology heterogeneity comorbidity and developmental trajectories of CVD risk factors including obesity hypertension and cardiovascular health Using the two datasets the main questions of the study were addressed How do genes and environment act and interact to create covariation between obesity and hypertension and were the genetic and environmental factors the same at all ages from childhood to late adolescence and adulthood in both sexes Areas of research included the following causes of individual differences in anthropometric and cardiovascular characteristics their covariation and developmental change or continuity in adolescence parent-offspring transmission prediction of cardiovascular risk and sex race and population differences in genetic and environmental contributions on cardiovascular risk factors
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL060688 | NIH | None | httpsreporternihgovquickSearchR01HL060688 |