Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001678
Status:
COMPLETED
Last Update Posted:
2017-10-06
First Post:
1999-11-03
Brief Title:
Genetics of Rheumatoid Arthritis
Sponsor:
National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Genetics of Rheumatoid Arthritis The North American Rheumatoid Arthritis Consortium
Status:
COMPLETED
Status Verified Date:
2014-06-20
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study attempts to identify the genes responsible for rheumatoid arthritis RA or inflammation of the joints It is known that genes play an important role in RA but their number and significance have not been determined RA tends to run in families This study will examine the DNA hereditary material of patients with RA and their family members to try to determine which chromosomess contain the genes responsible for the disease
Patients with rheumatoid arthritis and their family members may be eligible for this study
Participants with RA who have a brother or sister with RA will undergo the following procedures
Review of their medical records
Medical history
Examination of the joints
Hand X-rays
Blood tests
Participants who 1 do not have RA but who have a relative with the disease or 2 have RA and a relative other than a brother or sister who has the disease will provide a blood sample or a buccal cheek cell sample Cheek cells are obtained by swishing a small amount of mouthwash in the mouth or by lightly bushing the inside of the cheek with a swab or brush
The samples will be tested for rheumatoid factor DNA studies and HLA type a blood type found on white blood cells Certain HLA types have been associated with an increased risk or severity of RA
Patients with rheumatoid arthritis and their family members may be eligible for this study
Participants with RA who have a brother or sister with RA will undergo the following procedures
Review of their medical records
Medical history
Examination of the joints
Hand X-rays
Blood tests
Participants who 1 do not have RA but who have a relative with the disease or 2 have RA and a relative other than a brother or sister who has the disease will provide a blood sample or a buccal cheek cell sample Cheek cells are obtained by swishing a small amount of mouthwash in the mouth or by lightly bushing the inside of the cheek with a swab or brush
The samples will be tested for rheumatoid factor DNA studies and HLA type a blood type found on white blood cells Certain HLA types have been associated with an increased risk or severity of RA
Detailed Description:
The purpose of this protocol is to identify genetic susceptibility loci for rheumatoid arthritis The Genetics and Genomics Branch of the Intramural Research Program of NIAMS now the
Inflammatory Diseases Section of the Intramural Research Program of NHGRI has joined with
several extramural centers to form the North American Rheumatoid Arthritis Consortium
NARAC The Consortium intends to identify and obtain clinical specimens on a total of 1000
sibling pairs with rheumatoid arthritis up to 100 sibling pairs will be recruited at the Clinical
Center Samples from parents and other family members will also be obtained where
appropriate Rheumatoid factors HLA-DR typings and hand films will be obtained on all
sibling pairs In addition DNA will be extracted from peripheral blood or buccal scrapings The
DNA from all 1000 sibling pairs will be typed for a set of approximately 350 genetic markers in
order to identify chromosomal regions likely to harbor genes conferring susceptibility to
rheumatoid arthritis For those chromosomal regions that are positive in this initial screen
families will be genotyped for additional markers to define disease-associated haplotypes and high density single nucleotide polymorphism SNP analysis will be conducted to narrow the regions of interest Candidate genes will be chosen from the narrowed regions of interest andor based on functional considerations and will be screened for mutations in rheumatoid arthritis
Inflammatory Diseases Section of the Intramural Research Program of NHGRI has joined with
several extramural centers to form the North American Rheumatoid Arthritis Consortium
NARAC The Consortium intends to identify and obtain clinical specimens on a total of 1000
sibling pairs with rheumatoid arthritis up to 100 sibling pairs will be recruited at the Clinical
Center Samples from parents and other family members will also be obtained where
appropriate Rheumatoid factors HLA-DR typings and hand films will be obtained on all
sibling pairs In addition DNA will be extracted from peripheral blood or buccal scrapings The
DNA from all 1000 sibling pairs will be typed for a set of approximately 350 genetic markers in
order to identify chromosomal regions likely to harbor genes conferring susceptibility to
rheumatoid arthritis For those chromosomal regions that are positive in this initial screen
families will be genotyped for additional markers to define disease-associated haplotypes and high density single nucleotide polymorphism SNP analysis will be conducted to narrow the regions of interest Candidate genes will be chosen from the narrowed regions of interest andor based on functional considerations and will be screened for mutations in rheumatoid arthritis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 98-HG-0124 | None | None | None |