Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005284
Status:
COMPLETED
Last Update Posted:
2016-03-16
First Post:
2000-05-25
Brief Title:
Epidemiology of Airway Responsiveness
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To prospectively identify factors that influence the rate of decline in pulmonary function and to identify predictors of chronic obstructive lung disease COLD and asthma in a population sample of older adults
Detailed Description:
BACKGROUND
Cigarette smoking is recognized as the most important factor in the development of chronic airflow obstruction yet only a minority of cigarette smokers develop clinical disease In 1985 interest focused on the role of increased levels of airways responsiveness and atopy as possible potentiating factors for the development of chronic airflow obstruction Then current epidemiologic studies had data on only one of these potential risk factors or were too small to adequately address the issues involved The present study assesses both airways responsiveness and atopy
DESIGN NARRATIVE
The study used the population and data base of the Veterans Administration Normative Aging Study NAS which began in 1963 The NAS population consists of over 1900 men originally selected for good health and their wives The NAS currently administers a cigarette smoking history questionnaire the NHLBI-ATS respiratory symptom and illness questionnaire and spirometry at regularly scheduled examinations three years apart The current study assessed airways responsiveness as measured by response to methacholine inhalation and atopy as measured by skin test blood eosinophilia and serum IgE in NAS participants when they returned for their next two examinations The data were used to examine the relationship of airways responsiveness atopy and cigarette smoking to respiratory symptoms both cross-sectionally and longitudinally
The study was renewed in 1996 to prospectively identify factors that influence the rate of decline in pulmonary function and to identify predictors of chronic obstructive lung disease COLD and asthma in a population sample of older adults The investigators hypothesize that the development of accelerated decline in FEV1 and the occurrence of respiratory symptoms in older adults are determined by two environmental exposures tobacco smoke-induced injury and IgE-mediated hypersensitivity to inhaled aeroallergens The extent to which allergen exposure and airway responsiveness lead to fixed airflow obstruction in older adults is unknown The primary allergens of interest include house dust mite Der p I Der fI cockroach Bla g I Bla g II cat Fel d I and fungi Airway hyperresponsiveness to bronchoconstricting stimuli is a physiologic characteristic that may be thought of both as a manifestation of airway disease and as an intrinsic host characteristic which predisposes to the development of airway disease and determines its clinical pattern They are using the extensive longitudinal information on respiratory symptoms and illnesses cigarette smoking pulmonary function airway responsiveness indices of atopy skin test total and antigen-specific IgE indices of inflammation eosinophil and leukocyte counts in peripheral blood and allergen levels in dust and air in NAS participants and their wives to address the following hypotheses that the association of increased airway responsiveness with accelerated longitudinal decline in pulmonary function is modified by gender smoking level of FEV1 and skin test reactivity that the level of exposure to common indoor allergens affects the rate of longitudinal decline of pulmonary function that high levels of exposure to common indoor allergens leads to longitudinal increases in airway responsiveness over time and that settled dust levels of fungi culturable and countable organisms and antigens cockroach Bla g l Bla g II and cat Fel d I are correlated with airborne levels of these agents
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Cigarette smoking is recognized as the most important factor in the development of chronic airflow obstruction yet only a minority of cigarette smokers develop clinical disease In 1985 interest focused on the role of increased levels of airways responsiveness and atopy as possible potentiating factors for the development of chronic airflow obstruction Then current epidemiologic studies had data on only one of these potential risk factors or were too small to adequately address the issues involved The present study assesses both airways responsiveness and atopy
DESIGN NARRATIVE
The study used the population and data base of the Veterans Administration Normative Aging Study NAS which began in 1963 The NAS population consists of over 1900 men originally selected for good health and their wives The NAS currently administers a cigarette smoking history questionnaire the NHLBI-ATS respiratory symptom and illness questionnaire and spirometry at regularly scheduled examinations three years apart The current study assessed airways responsiveness as measured by response to methacholine inhalation and atopy as measured by skin test blood eosinophilia and serum IgE in NAS participants when they returned for their next two examinations The data were used to examine the relationship of airways responsiveness atopy and cigarette smoking to respiratory symptoms both cross-sectionally and longitudinally
The study was renewed in 1996 to prospectively identify factors that influence the rate of decline in pulmonary function and to identify predictors of chronic obstructive lung disease COLD and asthma in a population sample of older adults The investigators hypothesize that the development of accelerated decline in FEV1 and the occurrence of respiratory symptoms in older adults are determined by two environmental exposures tobacco smoke-induced injury and IgE-mediated hypersensitivity to inhaled aeroallergens The extent to which allergen exposure and airway responsiveness lead to fixed airflow obstruction in older adults is unknown The primary allergens of interest include house dust mite Der p I Der fI cockroach Bla g I Bla g II cat Fel d I and fungi Airway hyperresponsiveness to bronchoconstricting stimuli is a physiologic characteristic that may be thought of both as a manifestation of airway disease and as an intrinsic host characteristic which predisposes to the development of airway disease and determines its clinical pattern They are using the extensive longitudinal information on respiratory symptoms and illnesses cigarette smoking pulmonary function airway responsiveness indices of atopy skin test total and antigen-specific IgE indices of inflammation eosinophil and leukocyte counts in peripheral blood and allergen levels in dust and air in NAS participants and their wives to address the following hypotheses that the association of increased airway responsiveness with accelerated longitudinal decline in pulmonary function is modified by gender smoking level of FEV1 and skin test reactivity that the level of exposure to common indoor allergens affects the rate of longitudinal decline of pulmonary function that high levels of exposure to common indoor allergens leads to longitudinal increases in airway responsiveness over time and that settled dust levels of fungi culturable and countable organisms and antigens cockroach Bla g l Bla g II and cat Fel d I are correlated with airborne levels of these agents
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL034645 | NIH | None | httpsreporternihgovquickSearchR01HL034645 |