Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006502
Status:
COMPLETED
Last Update Posted:
2016-02-29
First Post:
2000-11-16
Brief Title:
Myocardial Perfusion Risk Factors and Coronary Calcium
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine whether an impairment of myocardial perfusion reserve is an early indicator of coronary artery disease
Detailed Description:
BACKGROUND
Impairment of coronary vasofunction is believed to be one of the earliest manifestations of coronary heart disease CHD The impact of risk factors such as elevated cholesterol levels diabetes hypertension and smoking on the coronary microcirculation remains largely unknown
DESIGN NARRATIVE
The cross-sectional study will determine whether an impairment of the myocardial perfusion reserve provides a marker of coronary heart disease CHD by comparing it to other novel measures of subclinical vascular disease and by testing its association with risk factors for CHD The study is ancillary to the Multi-Ethnic Study of Atherosclerosis MESA which is an NHLBI funded prospective observational study of the characteristics of subclinical cardiovascular disease ie disease detected non-invasively before it has produced signs and symptoms In MESA new measures of subclinical disease such as coronary artery calcium and impaired brachial artery reactivity are to be examined to investigate their relationships to well-established risk factors and clinical events Myocardial perfusion reserve MPRis a useful measure of coronary vasofunction that should be included in an evaluation of new measures of subclinical disease An impaired MPR appears to be a specific early indicator of the functional impairment of the microcirculation in patients with risk factors for coronary artery disease Magnetic resonance imaging MRI will be used as an advanced quantitative imaging modality to determine in short 20 minute exams the myocardial perfusion reserve in a group of 400 MESA participants The study tests the hypothesis that impaired myocardial perfusion reserve indicates the presence of subclinical coronary atherosclerosis and coronary microvascular disease
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Impairment of coronary vasofunction is believed to be one of the earliest manifestations of coronary heart disease CHD The impact of risk factors such as elevated cholesterol levels diabetes hypertension and smoking on the coronary microcirculation remains largely unknown
DESIGN NARRATIVE
The cross-sectional study will determine whether an impairment of the myocardial perfusion reserve provides a marker of coronary heart disease CHD by comparing it to other novel measures of subclinical vascular disease and by testing its association with risk factors for CHD The study is ancillary to the Multi-Ethnic Study of Atherosclerosis MESA which is an NHLBI funded prospective observational study of the characteristics of subclinical cardiovascular disease ie disease detected non-invasively before it has produced signs and symptoms In MESA new measures of subclinical disease such as coronary artery calcium and impaired brachial artery reactivity are to be examined to investigate their relationships to well-established risk factors and clinical events Myocardial perfusion reserve MPRis a useful measure of coronary vasofunction that should be included in an evaluation of new measures of subclinical disease An impaired MPR appears to be a specific early indicator of the functional impairment of the microcirculation in patients with risk factors for coronary artery disease Magnetic resonance imaging MRI will be used as an advanced quantitative imaging modality to determine in short 20 minute exams the myocardial perfusion reserve in a group of 400 MESA participants The study tests the hypothesis that impaired myocardial perfusion reserve indicates the presence of subclinical coronary atherosclerosis and coronary microvascular disease
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL065580 | NIH | None | httpsreporternihgovquickSearchR01HL065580 |