Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005545
Status:
COMPLETED
Last Update Posted:
2013-12-12
First Post:
2000-05-25
Brief Title:
Arterial Endothelial Function--An Epidemiologic Study
Sponsor:
University of Iowa
Organization:
University of Iowa
Study Overview
Official Title:
Arterial Endothelial Function--An Epidemiologic Study
Status:
COMPLETED
Status Verified Date:
2013-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine if risk factors measured in childhood can predict the development of atherosclerotic coronary and carotid artery disease in adulthood
Detailed Description:
BACKGROUND
Many young adult subjects have some degree of atherosclerotic coronary and carotid artery disease and experience no symptoms As time passes many die suddenly and unexpectedly and only limited therapeutic process begins in youth a measure of the early manifestations of atherosclerosis may have the potential of identifying subjects at risk for premature coronary and carotid occlusive vascular disease when therapeutic options can be administered Impaired brachial artery flow mediated dilatory FMD capacities have been shown to exist in children and young adults with hypercholesterolemia hyperhomocysteinemia diabetes and in those who smoke Impaired brachial artery FMD has been shown to related to impaired endothelial function which is an early manifestation of the atherosclerotic process If impaired brachial artery FMD is a predictor of the process then it may be used to non-invasively assess atherosclerosis early in its development and to evaluate the effect of therapeutic interventions
DESIGN NARRATIVE
In this longitudinal study using previously studied members of the Muscatine study measurements are made of contemporaneous risk factors and brachial artery FMD along with coronary artery calcification CAC and carotid artery intimal-medial thickness IMT the latter two established measures of early atherosclerosis and again three years later The effort is designed to examine the following hypotheses 1 Established risk factor levels measured in childhood adulthood and across the years form childhood through adulthood are predictive of brachial artery flow mediated dilatory FMD capacities 2 Putative risk factor levels measured in adulthood are related to the degree of brachial artery FMD CAC and carotid artery IMT 3 Brachial artery FMD CAC and carotid artery IMTare related in adults and 4 Brachial artery FMD is predictive of increased carotid artery IMT
Many young adult subjects have some degree of atherosclerotic coronary and carotid artery disease and experience no symptoms As time passes many die suddenly and unexpectedly and only limited therapeutic process begins in youth a measure of the early manifestations of atherosclerosis may have the potential of identifying subjects at risk for premature coronary and carotid occlusive vascular disease when therapeutic options can be administered Impaired brachial artery flow mediated dilatory FMD capacities have been shown to exist in children and young adults with hypercholesterolemia hyperhomocysteinemia diabetes and in those who smoke Impaired brachial artery FMD has been shown to related to impaired endothelial function which is an early manifestation of the atherosclerotic process If impaired brachial artery FMD is a predictor of the process then it may be used to non-invasively assess atherosclerosis early in its development and to evaluate the effect of therapeutic interventions
DESIGN NARRATIVE
In this longitudinal study using previously studied members of the Muscatine study measurements are made of contemporaneous risk factors and brachial artery FMD along with coronary artery calcification CAC and carotid artery intimal-medial thickness IMT the latter two established measures of early atherosclerosis and again three years later The effort is designed to examine the following hypotheses 1 Established risk factor levels measured in childhood adulthood and across the years form childhood through adulthood are predictive of brachial artery flow mediated dilatory FMD capacities 2 Putative risk factor levels measured in adulthood are related to the degree of brachial artery FMD CAC and carotid artery IMT 3 Brachial artery FMD CAC and carotid artery IMTare related in adults and 4 Brachial artery FMD is predictive of increased carotid artery IMT
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R37HL061857 | NIH | None | httpsreporternihgovquickSearchR37HL061857 |