Ignite Creation Date:
2024-05-05 @ 5:33 PM
Last Modification Date:
2024-10-26 @ 9:32 AM
Study NCT ID:
NCT00473460
Status:
COMPLETED
Last Update Posted:
2014-10-28
First Post:
2007-05-14
Brief Title:
Intermittent Moxifloxacin Therapy For The Prevention Of Acute Exacerbations In Patients With Chronic Bronchitis
Sponsor:
Bayer
Organization:
Bayer
Study Overview
Official Title:
A Double-blind Randomized Placebo-controlled Study to Investigate Chronic Intermittent-pulse-therapy of Moxifloxacin as a Prevention of Acute in Exacerbation Out-patients With Chronic Bronchitis
Status:
COMPLETED
Status Verified Date:
2014-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Moxifloxacin is being tested at approximately 60 study centres in 15 countries to determine if this drug when taken periodically in addition to the patients normal treatment is effective at reducing the number of flare-ups of chronic bronchitis he has Approximately 1132 subjects will participate and it is expected that the study will run for 2 years in order to reach that goal The patients individual involvement in the study will be 17 months Moxifloxacin will be compared to a placebo drug no active ingredients The study medication moxifloxacin or placebo will be taken in addition to the patients normal medication for chronic bronchitis In addition to the first clinic visit called a screening visit the patient will be required to come back to the clinic for ten more study visits every 8 weeks At the first visit the study co-ordinator will provide him with the dates for all the visits Over a period of 48 weeks the patient will return to the clinic on 6 occasions where he will receive the study medication which he will take for five days in addition to his normal treatment for chronic bronchitis After this time the patient will enter a follow up period for 24 weeks where he will come to the clinic for assessments and continue to take his normal medication but not receive the study drug A complete medical history will be taken at the first visit including the patients past and current smoking habit A breath test will be performed to assess how well his lungs are functioning In addition he will also be asked to provide a sputum sample for a microbiological examination to identify any bacteria present in the sample The patient must be able to provide a sputum sample at the screening visit If the patient meets all the inclusion exclusion criteria for the study he will be allocated randomly to one of the following treatment groups at the second visit- Treatment group 1 Receives moxifloxacin orally once daily for five days- Treatment group 2 Receives a matching placebo once daily for five daysIn between each visit four weeks after your clinic visit the study site co-ordinator will contact the patient to check on his well being If the patient or the doctor decides to stop the patients participation in the trial for any reason the patient will be required to return to the clinic for a physical examination take a breath test provide a sputum sample if possible and have a blood sample taken
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| EudraCT No 2004-000404-40 | None | None | None |