Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005709
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Lipoprotein Metabolism in Hypertensive African-Americans
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2001-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To study relationships among lipoprotein metabolism hypertension and hyperinsulinemia-insulin resistance in African American males and females The study was part of a Collaborative Project on Minority Health which investigated the mechanisms by which insulin contributes to cardiovascular disease
Detailed Description:
BACKGROUND
The study was part of the initiative Collaborative Projects R01s on Minority Health The concept for the initiative was developed by the NHLBI staff after the 1993 Report of the Committee on Appropriations House of Representatives encouraged the NHLBI to establish minority centers to facilitate the diagnosis and treatment of cardiovascular diseases The initiative was approved at the September 1992 National Heart Lung and Blood Advisory Council and released in October 1992
Julian Marsh was one of three investigators in a collaborative program with Bonita Falkner as Program Coordinator
DESIGN NARRATIVE
In a sub-set of subjects with either high or low plasma insulin levels after a glucose challenge insulin sensitive or insulin resistant the investigators determined the fractional and absolute synthesis and catabolic rates of apolipoproteins B and A-I the dominant lipoproteins of Low Density Lipoprotein LDL and High Density Lipoprotein HDL They used stable isotopes and multicompartmental kinetic analysis following an oral bolus dose of deuteroleucine They hypothesized that in hypertensive African Americans with hyperinsulinemia more of the smaller Very Low Density VLDL particles are secreted and converted to LDL
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
The study was part of the initiative Collaborative Projects R01s on Minority Health The concept for the initiative was developed by the NHLBI staff after the 1993 Report of the Committee on Appropriations House of Representatives encouraged the NHLBI to establish minority centers to facilitate the diagnosis and treatment of cardiovascular diseases The initiative was approved at the September 1992 National Heart Lung and Blood Advisory Council and released in October 1992
Julian Marsh was one of three investigators in a collaborative program with Bonita Falkner as Program Coordinator
DESIGN NARRATIVE
In a sub-set of subjects with either high or low plasma insulin levels after a glucose challenge insulin sensitive or insulin resistant the investigators determined the fractional and absolute synthesis and catabolic rates of apolipoproteins B and A-I the dominant lipoproteins of Low Density Lipoprotein LDL and High Density Lipoprotein HDL They used stable isotopes and multicompartmental kinetic analysis following an oral bolus dose of deuteroleucine They hypothesized that in hypertensive African Americans with hyperinsulinemia more of the smaller Very Low Density VLDL particles are secreted and converted to LDL
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL051536 | NIH | None | httpsreporternihgovquickSearchR01HL051536 |