Ignite Creation Date:
2024-05-06 @ 5:20 PM
Last Modification Date:
2024-10-26 @ 2:27 PM
Study NCT ID:
NCT05275751
Status:
COMPLETED
Last Update Posted:
2023-03-17
First Post:
2022-02-22
Brief Title:
Mechanisms of Human Heat Perception - Involvement of TRPA1 TRPV1 and TRPM3
Sponsor:
Medical University of Vienna
Organization:
Medical University of Vienna
Study Overview
Official Title:
Human Heat Sensation - a Single-group Randomized Placebo-controlled Adaptive Full-factorial Crossover Trial
Status:
COMPLETED
Status Verified Date:
2023-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Animal studies suggest that the ion channels TRPV1 TRPA1 and TRPM3 are the relevant heat sensors This study aims to validate these findings in humans
Detailed Description:
Surprisingly it is still not fully understood how humans perceive heat pain There are several heat-sensitive ion channels whose manipulation in animals resulted in a more or less pronounced phenotype However complete blockade of heat sensation in animals has only recently been achieved In triple knockout mice lacking TRPA1 TRPV1 and TRPM3 it was recently shown that only in the absence of all three receptors heat perception is largely abolished Although the authors were unable to elucidate the underlying mechanism of this redundancy the redundancy appears to have evolutionary value for protection against burns In addition recent evidence suggests that TRPV1 plays a role as a first-line defense against heat injury ie that it encodes noninjurious heat injury in humans
The goal of this study is to test whether the redundant functions of TRPV1 TRPA1 and TRPM3 observed in mice with respect to heat perception also apply to humans More broadly we want to understand which receptors enable humans to perceive heat pain The study also aims to test if a chloride channel is involved in heat perception
Design Cross-over study with a Williams design group 16 treatments incl a placebo control
The goal of this study is to test whether the redundant functions of TRPV1 TRPA1 and TRPM3 observed in mice with respect to heat perception also apply to humans More broadly we want to understand which receptors enable humans to perceive heat pain The study also aims to test if a chloride channel is involved in heat perception
Design Cross-over study with a Williams design group 16 treatments incl a placebo control
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None