Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006076
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2000-07-28
Brief Title:
Genetic Studies of Tone Deafness
Sponsor:
National Institute on Deafness and Other Communication Disorders NIDCD
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Genetic Studies of Tune Deafness
Status:
COMPLETED
Status Verified Date:
2010-06-29
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine the hereditary basis of tone deafness by identifying regions of the human genome linked to this condition Both exceptionally good pitch recognition perfect pitch and exceptionally poor pitch recognition tone deafness run in families A better understanding of what causes tone deafness may provide new insights into auditory hearing function
Individuals with two or more family members 15 years of age or older who are tone deaf or have trouble recognizing different melodies may be eligible for this study Candidates will be screened with a short listening test for pitch and a short written test Those identified with poor pitch recognition will fill out a brief questionnaire about their family tree and family members without identifying names who have trouble recognizing melodies or tones Individuals with poor pitch recognition will be asked to help contact family members who may be interested in participating
Members of families with two or more first-degree relatives parents grandparents siblings who are tone deaf may enroll in the study They will provide a blood sample about 2 tablespoons for genetic studies and may take a 20-minute hearing test using headphones
Individuals with two or more family members 15 years of age or older who are tone deaf or have trouble recognizing different melodies may be eligible for this study Candidates will be screened with a short listening test for pitch and a short written test Those identified with poor pitch recognition will fill out a brief questionnaire about their family tree and family members without identifying names who have trouble recognizing melodies or tones Individuals with poor pitch recognition will be asked to help contact family members who may be interested in participating
Members of families with two or more first-degree relatives parents grandparents siblings who are tone deaf may enroll in the study They will provide a blood sample about 2 tablespoons for genetic studies and may take a 20-minute hearing test using headphones
Detailed Description:
The primary goal of this study is to identify regions of the genome which show genetic linkage to deficits in pitch recognition Pitch recognition in subjects will be tested to identify individuals and families with poor pitch recognition known as tune deafness defined as the inability to recognize wrong notes in a popular melody We will undertake a 2-stage process first a screening to identify probands and secondly a full family ascertainment and enrollment Probands and family members will be given an auditory and verbal attention test and additions listening tests to measure aspects of center auditory processing and attention Family phenotypic data will be used for additional epidemiological studies of tune deafness Affected and unaffected members of families containing multiple tune deaf individuals will have 20 cc of blood drawn to obtain DNA These DNA samples will then be genotyped using markers distributed across the human genome and the genotypic information analyzed to determine which markers show linkage to tune deafness Genetic linkage is the initial step in the process of positional cloning and cloning the defective genes which underlie tune deafness is a long term goal of this research
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 00-DC-0176 | None | None | None |