Ignite Creation Date:
2024-05-05 @ 9:45 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005472
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Job Strain Ambulatory Blood Pressure and Hypertension
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To analyze the association between an objective measure of job strain and risk of stroke and change in ambulatory blood pressure
Detailed Description:
BACKGROUND
Cardiovascular disease accounts for 43 percent of all deaths in the United States Hypertension affects as many as 50 million Americans however the causes of essential hypertension are not well known A new CVD risk factor job strain has emerged as a potential major cause of essential hypertension By 1995 over 20 studies had found significant positive relationships between job strain and CVD coronary heart disease all-cause mortality or hypertension Job strain is defined as high psychological workload demands combined with lowdecision latitude An expanded concept of job strain which included low workplace social support iso-strain was developed and examined in the study
Important questions remained to be answered about job strain CVD and hypertension In most studies job strain was only measured at one point in time while in fact cumulative exposure to job strain was believed to be the risk factor In addition most studies relied on self-report measures of job strain Also no studies specifically examined risk of stroke and job strain
DESIGN NARRATIVE
Data from the Cornell University cohort study of Psychosocial Factors and Cardiovascular Disease and the Columbia University-Northern Manhattan Stroke Study were analyzed The study had five specific aims including to determine whether blood pressure levels were associated with cumulative exposure to job strain differences in blood pressure increases were associated with an objective measure of job strain increased risk of stroke was associated with an objective measure of job strain changes in psychological variables over time were associated with job characteristics changes in CVD risk factors other than hypertension were associated with job characteristics
Paul Landsbergis also constructed measures of cumulative exposure to job strain and determined their association with blood pressure and analyzed the association between job characteristics and change in psychological variables and cardiovascular disease CVD risk factors
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Cardiovascular disease accounts for 43 percent of all deaths in the United States Hypertension affects as many as 50 million Americans however the causes of essential hypertension are not well known A new CVD risk factor job strain has emerged as a potential major cause of essential hypertension By 1995 over 20 studies had found significant positive relationships between job strain and CVD coronary heart disease all-cause mortality or hypertension Job strain is defined as high psychological workload demands combined with lowdecision latitude An expanded concept of job strain which included low workplace social support iso-strain was developed and examined in the study
Important questions remained to be answered about job strain CVD and hypertension In most studies job strain was only measured at one point in time while in fact cumulative exposure to job strain was believed to be the risk factor In addition most studies relied on self-report measures of job strain Also no studies specifically examined risk of stroke and job strain
DESIGN NARRATIVE
Data from the Cornell University cohort study of Psychosocial Factors and Cardiovascular Disease and the Columbia University-Northern Manhattan Stroke Study were analyzed The study had five specific aims including to determine whether blood pressure levels were associated with cumulative exposure to job strain differences in blood pressure increases were associated with an objective measure of job strain increased risk of stroke was associated with an objective measure of job strain changes in psychological variables over time were associated with job characteristics changes in CVD risk factors other than hypertension were associated with job characteristics
Paul Landsbergis also constructed measures of cumulative exposure to job strain and determined their association with blood pressure and analyzed the association between job characteristics and change in psychological variables and cardiovascular disease CVD risk factors
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R03HL055165 | NIH | None | httpsreporternihgovquickSearchR03HL055165 |