Ignite Creation Date:
2024-05-05 @ 9:45 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005188
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Quantitative Genetic Analysis of Lipid Research Clinic Family Data
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To assess the mode of inheritance of familial combined hyperlipidemia and familial primary hypoalphalipoproteinemia and to resolve genetic and familial environmental effects on several phenotypes of importance to coronary heart disease
Detailed Description:
BACKGROUND
Although coronary heart disease has long been known to aggregate in families in 1986 little was known about the relative importance of genetic and environmental factors This was partly due to the heterogeneous nature of the disease Instead of analyzing complex endpoints the tendency had been to focus on the individual risk factors or phenotypes Plasma lipids and lipoproteins are heterogeneous risk factors that have been analyzed as subgroups from a genetic epidemiological perspective Attention turned to the familial aggregation of risk factors particularly the hyperlipidemias hypertension and diabetes
In 1971 the National Heart and Lung Institute began a series of epidemiologic studies at several North American sites under the Lipid Research Clinics Program The Family Study was designed to investigate the familial association of blood lipids lipoproteins and dyslipoproteinemias This study complemented and did not duplicate ongoing analysis of Lipid Research Clinics data
DESIGN NARRATIVE
The study addressed seven phenotypes all derived from fasting blood samples total cholesterol total triglyceride LDL-cholesterol HDL-cholesterol VLDL-cholesterol uric acid and glucose levels The data had already been collected at Lipid Research Clinics in Cincinnati Iowa Oklahoma Minneapolis and Stanford Univariate and bivariate segregation analysis were conducted on the mode of inheritance of familial combined hyperlipidemia and familial primary hypoalphalipoproteinemia Path analysis was used to resolve cultural and biological inheritance for each phenotype within each clinic and for resolution of population heterogeneity among the five Lipid Research Clinics A general bivariate path model was used to analyze the associations among the various phenotypes General models were used to analyze temporal trends in family resemblance for the seven phenotypes
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Although coronary heart disease has long been known to aggregate in families in 1986 little was known about the relative importance of genetic and environmental factors This was partly due to the heterogeneous nature of the disease Instead of analyzing complex endpoints the tendency had been to focus on the individual risk factors or phenotypes Plasma lipids and lipoproteins are heterogeneous risk factors that have been analyzed as subgroups from a genetic epidemiological perspective Attention turned to the familial aggregation of risk factors particularly the hyperlipidemias hypertension and diabetes
In 1971 the National Heart and Lung Institute began a series of epidemiologic studies at several North American sites under the Lipid Research Clinics Program The Family Study was designed to investigate the familial association of blood lipids lipoproteins and dyslipoproteinemias This study complemented and did not duplicate ongoing analysis of Lipid Research Clinics data
DESIGN NARRATIVE
The study addressed seven phenotypes all derived from fasting blood samples total cholesterol total triglyceride LDL-cholesterol HDL-cholesterol VLDL-cholesterol uric acid and glucose levels The data had already been collected at Lipid Research Clinics in Cincinnati Iowa Oklahoma Minneapolis and Stanford Univariate and bivariate segregation analysis were conducted on the mode of inheritance of familial combined hyperlipidemia and familial primary hypoalphalipoproteinemia Path analysis was used to resolve cultural and biological inheritance for each phenotype within each clinic and for resolution of population heterogeneity among the five Lipid Research Clinics A general bivariate path model was used to analyze the associations among the various phenotypes General models were used to analyze temporal trends in family resemblance for the seven phenotypes
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL033973 | NIH | None | httpsreporternihgovquickSearchR01HL033973 |