Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001459
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Analysis of Heart Muscle Function in Patients With Heart Disease and Normal Volunteers
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Tomographic Myocardial Wall Motion Analysis in Patients With Myocardial Ischemia and in Normal Subjects
Status:
COMPLETED
Status Verified Date:
2000-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Myocardial ischemia is a heart condition in which not enough blood supply and oxygen reaches the heart muscle Damage to the major blood vessels of the heart coronary artery disease minor blood vessels of the heart microvascular heart disease or damage to the heart muscle hypertrophic cardiomyopathy can cause myocardial ischemia Any of theses three conditions can cause patients to experience chest pain and other symptoms as well as cause the heart to function improperly
In order to detect myocardial ischemia researchers can use tests to measure the movement of the walls of the heart Walls receiving inadequate supplies of blood often move less and occasionally move in the opposite direction Some of the tests may require patients to receive injections of radioactive tracers The radioactive material acts to enhance 3 dimensional pictures of the heart and helps to identify areas of ischemia
The purpose of this study is to determine whether 3-dimensional imaging tomography with radioactive tracers can provide more important information about heart wall function than routine diagnostic tests
In order to detect myocardial ischemia researchers can use tests to measure the movement of the walls of the heart Walls receiving inadequate supplies of blood often move less and occasionally move in the opposite direction Some of the tests may require patients to receive injections of radioactive tracers The radioactive material acts to enhance 3 dimensional pictures of the heart and helps to identify areas of ischemia
The purpose of this study is to determine whether 3-dimensional imaging tomography with radioactive tracers can provide more important information about heart wall function than routine diagnostic tests
Detailed Description:
We propose to assess regional myocardial function using gated blood pool imaging acquired by a tomographic technique at rest and during stress in patients with myocardial ischemia coronary artery disease hypertrophic cardiomyopathy and microvascular angina Gender differences in response to exercise and pharmacologic stress will also be evaluated Normal subjects will be studied in order to establish a control database Current methods of gated blood pool studies use planar imaging with its attendant limitations poor resolution and inadequate separation of the myocardial segments only one view assessed during exercise and superimposition of overlying structures Tomographic imaging has the advantages of reconstructing 3-dimensional data of the entire heart with the ability to improve segmental resolution and separate overlapping structures potentially resulting in increased sensitivity and specificity for detection of disease
The role of pharmacologic stress will be assessed by comparison with exercise stress in order to validate its use in subjects unable to exercise and identify gender related differences Quantitative measures of regional wall motion obtained from tomography will be compared to regions of prior myocardial infarction if present and with other modalities for evaluating cardiac structure and function The diagnostic and prognostic value of tomographic wall motion analysis will be studied in patients with myocardial ischemia with special emphasis on correlation between physiologic variables of coronary blood flow and metabolic function
The role of pharmacologic stress will be assessed by comparison with exercise stress in order to validate its use in subjects unable to exercise and identify gender related differences Quantitative measures of regional wall motion obtained from tomography will be compared to regions of prior myocardial infarction if present and with other modalities for evaluating cardiac structure and function The diagnostic and prognostic value of tomographic wall motion analysis will be studied in patients with myocardial ischemia with special emphasis on correlation between physiologic variables of coronary blood flow and metabolic function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 95-H-0048 | None | None | None |