Ignite Creation Date:
2024-05-06 @ 5:53 PM
Last Modification Date:
2024-10-26 @ 2:37 PM
Study NCT ID:
NCT05466825
Status:
COMPLETED
Last Update Posted:
2022-11-22
First Post:
2022-07-18
Brief Title:
Global Cardiovascular Risk Consortium
Sponsor:
Universitätsklinikum Hamburg-Eppendorf
Organization:
Universitätsklinikum Hamburg-Eppendorf
Study Overview
Official Title:
Impact of Modifiable Cardiovascular Risk Factors on Incident Cardiovascular Disease by Geographical Region and Sex
Status:
COMPLETED
Status Verified Date:
2022-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The Global Cardiovascular Risk Consortium GCVRC comprises harmonized data from nearly 17 Mio individuals of 126 cohorts across 43 countries and aims to elucidate the distribution of five major cardiovascular risk factors body mass index systolic blood pressure non-high-density lipoprotein cholesterol current smoking and diabetes and their impact on cardiovascular disease CVD by geographical region and sex
Detailed Description:
Previous literature reported a small number of modifiable risk factors that might explain up to 90 of certain CVD subtypes If and to what extent regional differences in risk factor levels contribute to new-onset CVD remains to be elucidated
In the Global Cardiovascular Risk Consortium GCVRC we focus on five major cardiovascular risk factors Body mass index systolic blood pressure non-high-density lipoprotein cholesterol current smoking and diabetes We aim to show the extent to which the distribution population attributable risk and predictive value of these factors differ geographically and by sex Understanding of these issues is essential to guide regionally effective CVD prevention and therapy strategies to determine residual risk and to improve global cardiovascular health
The GCVRC uses individual-level harmonized data from nearly 17 million individuals in 126 cohorts across 43 countries categorized in 8 geographical regions based on amodification of WHO regions - North America Latin America Sub-Saharan Africa North Africa and Middle East Western Europe Eastern Europe and Russia Asia Oceania
Cox regression analyses and population attributable fractions PAFs for 10-year incident CVD are calculated for the five risk factors by geographical region and sex to determine the percentage of CVD burden that may be preventable by control of these risk factors
The results will influence regionally adapted prevention strategies to reduce the global CVD burden
In the Global Cardiovascular Risk Consortium GCVRC we focus on five major cardiovascular risk factors Body mass index systolic blood pressure non-high-density lipoprotein cholesterol current smoking and diabetes We aim to show the extent to which the distribution population attributable risk and predictive value of these factors differ geographically and by sex Understanding of these issues is essential to guide regionally effective CVD prevention and therapy strategies to determine residual risk and to improve global cardiovascular health
The GCVRC uses individual-level harmonized data from nearly 17 million individuals in 126 cohorts across 43 countries categorized in 8 geographical regions based on amodification of WHO regions - North America Latin America Sub-Saharan Africa North Africa and Middle East Western Europe Eastern Europe and Russia Asia Oceania
Cox regression analyses and population attributable fractions PAFs for 10-year incident CVD are calculated for the five risk factors by geographical region and sex to determine the percentage of CVD burden that may be preventable by control of these risk factors
The results will influence regionally adapted prevention strategies to reduce the global CVD burden
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None