Ignite Creation Date:
2025-12-24 @ 6:48 PM
Ignite Modification Date:
2025-12-28 @ 6:53 AM
Study NCT ID:
NCT02524457
Status:
UNKNOWN
Last Update Posted:
2015-08-14
First Post:
2015-08-11
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
How Menopause Affects Lipid Metabolism in the Visceral Fat Depots
Sponsor:
Rigshospitalet, Denmark
Organization:
Study Overview
Official Title:
How Menopause Affects Lipid Metabolism in the Visceral Fat Depots
Status:
UNKNOWN
Status Verified Date:
2015-08
Last Known Status:
NOT_YET_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of the study is to describe the molecular mechanisms related to an increased visceral fat mass and changed T-cell homeostasis. the project is expected to add new knowledge to the field of metabolic diseases after menopause and increase the focus of how lipid affects the development of metabolic disease in relation to the menopausal transition.
Detailed Description:
The study is a cross sectional study including 60 women between 45 and 55 years of age. Investigators aim to include 20 premenopausal women, 20 postmenopausal women and 20 postmenopausal women taking hormone treatment (HT). All the women are going through gynecological surgery for benign reasons. During the operation investigators will take a visceral fat biopsy from the omentum.
maximally 1 month before- or after the operation the subject will meet at the lab for further testing, including:
* Health examination
* Blood samples
* OGTT
* DXA scan
* VO2 max testing
* MRI of the abdomen
* hyperinsulinemic euglycemic clamp
maximally 1 month before- or after the operation the subject will meet at the lab for further testing, including:
* Health examination
* Blood samples
* OGTT
* DXA scan
* VO2 max testing
* MRI of the abdomen
* hyperinsulinemic euglycemic clamp
Study Oversight
Has Oversight DMC:
True
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?: