Ignite Creation Date:
2024-05-06 @ 5:55 PM
Last Modification Date:
2024-10-26 @ 2:38 PM
Study NCT ID:
NCT05487989
Status:
RECRUITING
Last Update Posted:
2022-12-14
First Post:
2022-07-11
Brief Title:
VIsual Pathways Model in Neuro-inflammatory Disorders
Sponsor:
University Hospital Lille
Organization:
University Hospital Lille
Study Overview
Official Title:
Study of the VIsual Pathways MODEL for a Better Understanding of Neurodegeneration in Inflammatory and Demyelinating Disorders of Central Nervous System
Status:
RECRUITING
Status Verified Date:
2022-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
VIP-MODEL
Brief Summary:
In neuroinflammatory diseases of the central nervous system CNS such as multiple sclerosis MS neuromyelitis optica spectrum disorders NMOSD and anti-MOG antibody-associated disorders MOGAD neuronal degeneration is the consequence of inflammatory and demyelinating lesions in the brain optic nerve and spinal cord Both white and grey matter are systematically affected Lesions of the perivascular spaces containing cerebrospinal fluid CSF and meningeal inflammation seem to play an important role in the pathophysiology of these neuroinflammatory diseases Currently the interrelation of all these aspects is not clearly established in the pathophysiology of these diseases In order to better understand the mechanisms that lead to and underlie the clinical disability of patients with these diseases we need in vivo study models that allow the in-depth study of the neurodegenerative process and the identification of its causes In this perspective we make the hypothesis that the visual pathways model is very relevant to measure neuro-axonal loss and to explore the different mechanisms involved in neurodegeneration during MS and other CNS demyelinating diseases Researchers have at their disposal many tools that allow them to analyse and quantify the neurodegenerative process in a reproducible and very precise manner from a structural and functional point of view while taking into account possible vascular involvement MRI optical coherence tomography - angiography etc
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2022-A01483-40 | OTHER | ID-RCB number ANSM | None |