Ignite Creation Date:
2024-05-05 @ 6:34 PM
Last Modification Date:
2024-10-26 @ 9:34 AM
Study NCT ID:
NCT00506428
Status:
UNKNOWN
Last Update Posted:
2009-04-29
First Post:
2007-04-27
Brief Title:
Effects of Chronic Sleep Restriction in Young and Older People
Sponsor:
National Institute on Aging NIA
Organization:
National Institute on Aging NIA
Study Overview
Official Title:
Sleep Aging and Circadian Rhythm Disorders
Status:
UNKNOWN
Status Verified Date:
2009-04
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this study is to examine the consequences of chronic sleep restriction on nighttime sleep daytime alertness performance and memory functions and metabolic and cardiovascular function and to determine if the consequences of chronic sleep restriction differ between healthy young and older adults
Detailed Description:
It has long been recognized that sleep patterns change with age A common feature of aging is the advance of the timing of sleep to earlier hours often earlier than desired Polysomnographically-recorded sleep in older people shows an increased number of awakenings a reduction of stages 3 and 4 SWS sleep and a flattening of REM sleep distribution throughout the night These age-related changes are found in even healthy individuals who are not taking medications and who are free from sleep disorders In addition to these sleep disturbances many older individuals curtail their sleep voluntarily reporting similar rates of sleep restriction sleeping less than 7 or less than 6 hours per night as young adults Whether voluntary or not insufficient sleep has medical safety and metabolic consequences In fact converging evidence in young adults suggests that sleep restriction per se may impair metabolism and that reduced sleep duration is associated with weight gain obesity diabetes cardiovascular disease and mortality
The study begins with 21 days of outpatient study in which the participants will be required to sleep for 10 hours each night in order to ensure they are well-rested This will be followed by a 39-day inpatient study The study will begin with 3 sleep satiation days during which all participants will be scheduled to sleep for 12 hours per night and have a 4 hour nap each afternoon This is followed by 3 baseline days in which the participants will follow the same sleep-wake schedule they were following at home Following this the participant will undergo 3 weeks of chronic sleep restriction while living on a non-24-hour schedule The participant will live on a schedule that is equivalent to 56 hours of sleep per 24 hours Following these 3 weeks the participant will be scheduled to again sleep for 10 hours per night for 10 nights
The study begins with 21 days of outpatient study in which the participants will be required to sleep for 10 hours each night in order to ensure they are well-rested This will be followed by a 39-day inpatient study The study will begin with 3 sleep satiation days during which all participants will be scheduled to sleep for 12 hours per night and have a 4 hour nap each afternoon This is followed by 3 baseline days in which the participants will follow the same sleep-wake schedule they were following at home Following this the participant will undergo 3 weeks of chronic sleep restriction while living on a non-24-hour schedule The participant will live on a schedule that is equivalent to 56 hours of sleep per 24 hours Following these 3 weeks the participant will be scheduled to again sleep for 10 hours per night for 10 nights
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 2P01AG009975-11 | NIH | None | httpsreporternihgovquickSearch2P01AG009975-11 |