Ignite Creation Date:
2024-05-05 @ 11:20 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001418
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
PET Scan in Patients With Neurocardiologic Disorders
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Positron Emission Tomographic PET Scanning of Sympathetic Innervation and Function in Patients With Neurocardiologic Disorders
Status:
COMPLETED
Status Verified Date:
2004-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to use PET scans in order to measure activity of the sympathetic nervous system The sympathetic nervous system is the portion of the nervous system that maintains a normal supply of blood and fuel to organs during stressful situations
PET scan or Positron Emission Tomography is an advanced form of an X-ray It is used to detect radioactive substances in the body During this study researchers plan to inject small amounts of the radioactive drug fluorodopamine into patients Fluorodopamine is very similar to the chemicals found in the sympathetic nervous system It can attach to sympathetic nerve endings and allow researchers to view them with the aid of a PET scan One area of the body with many sympathetic nerve endings is the heart After giving a dose of fluorodopamine researchers will be able to visualize all of the sympathetic nerve endings involved in the activity of the heart In addition this diagnostic test will help researchers detect abnormalities of the nervous system of patients hearts
PET scan or Positron Emission Tomography is an advanced form of an X-ray It is used to detect radioactive substances in the body During this study researchers plan to inject small amounts of the radioactive drug fluorodopamine into patients Fluorodopamine is very similar to the chemicals found in the sympathetic nervous system It can attach to sympathetic nerve endings and allow researchers to view them with the aid of a PET scan One area of the body with many sympathetic nerve endings is the heart After giving a dose of fluorodopamine researchers will be able to visualize all of the sympathetic nerve endings involved in the activity of the heart In addition this diagnostic test will help researchers detect abnormalities of the nervous system of patients hearts
Detailed Description:
This project applies positron emission tomographic PET scanning after administration of 6-18Ffluorodopamine 18F-6F-DA to visualize sympathetic innervation and function in patients with neurocardiologic disorders Patients undergo infusion of 18F-6F-DA followed by PET scanning of one or more body regions Patients may also undergo PET scanning after administration of 13N-ammonia to assess regional perfusion regional blood sampling including sampling from the coronary sinus or great cardiac vein during infusion of 3H-l-norepinephrine 3H-NE to assess the kinetics and metabolism of NE or magnetic resonance imaging MRI to delineate the ventricular myocardium PET scanning after 18F-6F-DA administration in conjunction with other clinical assessment tools should provide comprehensive information about regional sympathoneural innervation and function in neurocardiologic disorders
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 94-N-0186 | None | None | None |