Ignite Creation Date:
2024-05-06 @ 6:15 PM
Last Modification Date:
2024-10-26 @ 2:44 PM
Study NCT ID:
NCT05604469
Status:
UNKNOWN
Last Update Posted:
2022-11-03
First Post:
2022-10-30
Brief Title:
The Role of Skin Microbiota in Hepatic or Renal Pruritus
Sponsor:
Zagazig University
Organization:
Zagazig University
Study Overview
Official Title:
The Role of Skin Microbiota in Patients With Hepatic or Renal Pruritus
Status:
UNKNOWN
Status Verified Date:
2022-10
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Various neurotransmitters may share in the pathogenesis of hepatic and renal itching
Skin microbiota may share in the pathogenesis of pruritus
Skin microbiota may share in the pathogenesis of pruritus
Detailed Description:
Uremic pruritus UP is a frequent phenomenon and it is regarded as one of the most bothersome symptoms in patients with chronic renal disease The prevalence of UP is still high and reported in around 40 to 50 UP has an important impact on patients quality of life and sleep depression and increased mortality The pathogenesis of UP remains blurry although many different factors have been indicated in the etiology of this symptom including increased systemic inflammation abnormal serum parathyroid hormone calcium and phosphorus levels an imbalance in opiate receptors a neuropathic process or even skin dryness This is why until now there is no specific treatment for patients with UP and many of the available therapeutic modalities are not satisfactory Pruritus in liver diseases can often be a debilitating symptom causing significant impairment in quality of life Not all patients with liver disease develop pruritus and its prevalence varies depending on the underlying cause of liver disease It is more common in conditions characterized by bile duct inflammatory destruction than in those characterized by hepatocellular injury
Cutaneous microbiota delivers a diverse and far-reaching influence on our physiology by calling upon the host nervous system Bacteria make metabolites toxins and structural components that are recognized by peripheral and central neurons via matching receptors Microbiota also indirectly affects neural function by causing endocrine ie keratinocytes and immune cells to transmit signals ie cytokines proteases Itch is a prototypic sensory neural function and the microbiota propels the itch-scratch cycle
Cutaneous microbiota delivers a diverse and far-reaching influence on our physiology by calling upon the host nervous system Bacteria make metabolites toxins and structural components that are recognized by peripheral and central neurons via matching receptors Microbiota also indirectly affects neural function by causing endocrine ie keratinocytes and immune cells to transmit signals ie cytokines proteases Itch is a prototypic sensory neural function and the microbiota propels the itch-scratch cycle
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None