Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005542
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Sarcoid Genetic Analysis SAGA
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2005-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To identify sarcoidosis susceptibility genes and to determine how these genes and environmental risk factors interact to cause sarcoidosis
Detailed Description:
BACKGROUND
Sarcoidosis is a rare systemic granulomatous disease that mainly affects young to middle aged adults and more severely affects African Americans than Caucasians The etiology of sarcoidosis is not yet known and epidemiological studies have only identified general risk factors including age sex race and family history Sarcoidosis may also be influenced by environmental factors although the particular environmental agents have not yet been clearly defined While previous studies have provided evidence for familial clustering little is known about the genes that influence predisposition to sarcoidosis
DESIGN NARRATIVE
This is a multicenter consortium genetic epidemiology study The investigators will accomplish their goal by organizing a 10-site multi-center consortium to recruit an adequate sample of sarcoidosis families for analysis They plan to use the affected sibling pair linkage analysis to scan the genome for linked chromosomal regions transmission disequilibrium testing to evaluate candidate genes in those regions with evidence for linkage and an environmental questionnaire to collect data to test for possible interactions of susceptibility genes with exogenous risk factors Genotyping and analysis of data are scheduled to begin in July 2001 with completion of all analysis by April 2004
The study consists of a Clinical Core a Data Coordinating Core and a Genetics Core with a DNA Processing Center and a Genotyping Center Eight of the ten clinical centers comprising the Clinical Core are members of the ACCESS A Case Control Etiology of Sarcoidosis Study
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Sarcoidosis is a rare systemic granulomatous disease that mainly affects young to middle aged adults and more severely affects African Americans than Caucasians The etiology of sarcoidosis is not yet known and epidemiological studies have only identified general risk factors including age sex race and family history Sarcoidosis may also be influenced by environmental factors although the particular environmental agents have not yet been clearly defined While previous studies have provided evidence for familial clustering little is known about the genes that influence predisposition to sarcoidosis
DESIGN NARRATIVE
This is a multicenter consortium genetic epidemiology study The investigators will accomplish their goal by organizing a 10-site multi-center consortium to recruit an adequate sample of sarcoidosis families for analysis They plan to use the affected sibling pair linkage analysis to scan the genome for linked chromosomal regions transmission disequilibrium testing to evaluate candidate genes in those regions with evidence for linkage and an environmental questionnaire to collect data to test for possible interactions of susceptibility genes with exogenous risk factors Genotyping and analysis of data are scheduled to begin in July 2001 with completion of all analysis by April 2004
The study consists of a Clinical Core a Data Coordinating Core and a Genetics Core with a DNA Processing Center and a Genotyping Center Eight of the ten clinical centers comprising the Clinical Core are members of the ACCESS A Case Control Etiology of Sarcoidosis Study
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| U01HL060263 | NIH | None | httpsreporternihgovquickSearchU01HL060263 |