Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005283
Status:
COMPLETED
Last Update Posted:
2016-02-18
First Post:
2000-05-25
Brief Title:
Risk Factors For Asthma in Laboratory Animal Allergy
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To identify risk factors which predispose individuals to develop asthma and other manifestations of allergic disease on exposure to laboratory animals in the workplace
Detailed Description:
BACKGROUND
In 1982 asthma and allergy to laboratory animals among persons who worked with the animals gained increased recognition as an occupational health problem affecting researchers veterinarians technicians animal handlers and others At that time more than 90000 workers across the United States were at risk due to their exposure to lab animals in the more than 1100 facilities registered by the United States Department of Agriculture Several surveys of exposed workers indicated a prevalence rate of allergic symptoms due to laboratory animal allergy ranging from 19-30 percent in animal workers Asthma was also a frequent disease among animal workers these surveys indicated that as many as 13-14 percent of exposed workers had asthma
The problem of laboratory animal allergy and asthma involved a vast industry that included medical and veterinary colleges research institutes and universities pharmaceutical manufacturers commercial laboratory animal producers and hospitals
DESIGN NARRATIVE
Recruitment for this longitudinal study began in November 1983 and ended in July 1987 The initial visit consisted of an extensive interview to identify and to exclude those individuals with laboratory animal allergy asthma and other manifestations of allergy and to obtain an occupational history Venipuncture was used to obtain serum for IgE and IgG antibody assays Pulmonary function tests including a methacholine challenge were administered Psychosocial questionnaires were administered Subjects were evaluated at six month intervals with skin tests venipuncture and methacholine challenge The degree of exposure to animal allergens was quantitated by aeroallergen sampling of workplace and personal breathing zone air and by work diaries
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
In 1982 asthma and allergy to laboratory animals among persons who worked with the animals gained increased recognition as an occupational health problem affecting researchers veterinarians technicians animal handlers and others At that time more than 90000 workers across the United States were at risk due to their exposure to lab animals in the more than 1100 facilities registered by the United States Department of Agriculture Several surveys of exposed workers indicated a prevalence rate of allergic symptoms due to laboratory animal allergy ranging from 19-30 percent in animal workers Asthma was also a frequent disease among animal workers these surveys indicated that as many as 13-14 percent of exposed workers had asthma
The problem of laboratory animal allergy and asthma involved a vast industry that included medical and veterinary colleges research institutes and universities pharmaceutical manufacturers commercial laboratory animal producers and hospitals
DESIGN NARRATIVE
Recruitment for this longitudinal study began in November 1983 and ended in July 1987 The initial visit consisted of an extensive interview to identify and to exclude those individuals with laboratory animal allergy asthma and other manifestations of allergy and to obtain an occupational history Venipuncture was used to obtain serum for IgE and IgG antibody assays Pulmonary function tests including a methacholine challenge were administered Psychosocial questionnaires were administered Subjects were evaluated at six month intervals with skin tests venipuncture and methacholine challenge The degree of exposure to animal allergens was quantitated by aeroallergen sampling of workplace and personal breathing zone air and by work diaries
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL030532 | NIH | None | httpsreporternihgovquickSearchR01HL030532 |