Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005145
Status:
COMPLETED
Last Update Posted:
2016-02-05
First Post:
2000-05-25
Brief Title:
Minnesota Heart Survey - Risk Factor Survey
Sponsor:
University of Minnesota
Organization:
University of Minnesota
Study Overview
Official Title:
Study of Trends in Cardiovascular Risk Factors in an Urban Population
Status:
COMPLETED
Status Verified Date:
2016-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MHS
Brief Summary:
To continue surveillance of cardiovascular disease risk factors in the seven-county area of Minneapolis-St Paul
Detailed Description:
BACKGROUND
Cardiovascular disease mortality rates especially for myocardial infarction and stroke have fallen markedly over the past several decades in all race sex and age groups in the United States Between 1966 and 1986 the combined death rate for all cardiovascular diseases declined by 42 percent In 1986 the death rate for coronary heart disease was 55 percent of what it had been in 1966 and cerebrovascular disease was 42 percent of what it had been in 1966 The decline is assumed to be related to several factors including improved medical care and risk factor modification for elevated blood lipids cigarette smoking and hypertension The Minnesota Heart Survey provide trends 1970-2002 in coronary heart disease deaths out-of-hospital in hospitalization rates case fatality and survivorship for myocardial infarction and stroke in the metropolitan area
DESIGN NARRATIVE
Between 1979 and 1999 R01HL23727 supported mortality surveillance and morbidity surveillance Beginning in FY 2000 R01HL65755 supports the morbidity and mortality surveillance and R01HL23727 supports the risk factor survey
Mortality Surveillance The mortality surveillance was a continuation of a surveillance study performed by the investigators since 1960 for the state of Minnesota Mortality data for hypertension stroke coronary heart disease and all cardiovascular renal disease were monitored for the Twin City metropolitan area with a total population of two million Age sex area location of death and cause-specific death rates were followed Trends in cancer diabetes and other non-cardiovascular disease were examined Case fatality rates including one- and five-year survivorships were determined and related to coronary heart disease mortality trends
Morbidity Surveillance All discharges from the seven-county area hospitals with acute and chronic myocardial heart disease and stroke listed among the discharge diagnoses were recorded using Professional Standards Review Organization data tapes A ten percent random sample of all recorded diagnoses were validated yearly by abstracting data from hospital records Each years validation sample of definite and probable cases of myocardial infarction and stroke formed a cohort to be followed for mortality for one year after the onset of the disease event Individual hospitals and the Professional Standards Review Organization in the area provided data on the total numbers of coronary care unit admissions and coronary artery bypass operations for each year Beginning in August 1988 a registry was established for all new incident cases of coronary heart disease at the University of Minnesota Hospital and the Ramsey County Hospital In 1989 twelve hospitals were part of the myocardial infarction registry
Risk Factor Surveillance Population samples aged 25-74 years are recruited and measured for blood pressure serum cholesterol serum high density lipoprotein cholesterol cigarette smoking diet physical activity height weight health attitudes and beliefs and coronary prone behavior Surveys were completed in 1980-1982 and 1984-1985 The third survey conducted in 1990-1992 included the Willett Food Frequency Questionnaire and bioimpedance measurements A nested case-control study using the 1980-1982 risk factor cohort examined the baseline cardiovascular disease risk factor differences between coronary heart disease in cases and controls
The study was renewed in the year 2000 under R01HL23727 to conduct a population survey of 4000 adults ages 25 to 84 in 2000-2002 to detect current trends in cardiovascular disease risk factors including serum lipids blood pressure cigarette smoking prevalence dietary fat intake obesity diabetes physical inactivity fibrinogen and serum vitamin E Cohort and ecological analyses will be used to link secular trends in risk factors to morbidity and mortality from coronary heart disease congestive heart failure and stroke A total of 1000 children and adolescents ages 8-17 will also be surveyed using youth-specific measurement instruments where appropriate
Cardiovascular disease mortality rates especially for myocardial infarction and stroke have fallen markedly over the past several decades in all race sex and age groups in the United States Between 1966 and 1986 the combined death rate for all cardiovascular diseases declined by 42 percent In 1986 the death rate for coronary heart disease was 55 percent of what it had been in 1966 and cerebrovascular disease was 42 percent of what it had been in 1966 The decline is assumed to be related to several factors including improved medical care and risk factor modification for elevated blood lipids cigarette smoking and hypertension The Minnesota Heart Survey provide trends 1970-2002 in coronary heart disease deaths out-of-hospital in hospitalization rates case fatality and survivorship for myocardial infarction and stroke in the metropolitan area
DESIGN NARRATIVE
Between 1979 and 1999 R01HL23727 supported mortality surveillance and morbidity surveillance Beginning in FY 2000 R01HL65755 supports the morbidity and mortality surveillance and R01HL23727 supports the risk factor survey
Mortality Surveillance The mortality surveillance was a continuation of a surveillance study performed by the investigators since 1960 for the state of Minnesota Mortality data for hypertension stroke coronary heart disease and all cardiovascular renal disease were monitored for the Twin City metropolitan area with a total population of two million Age sex area location of death and cause-specific death rates were followed Trends in cancer diabetes and other non-cardiovascular disease were examined Case fatality rates including one- and five-year survivorships were determined and related to coronary heart disease mortality trends
Morbidity Surveillance All discharges from the seven-county area hospitals with acute and chronic myocardial heart disease and stroke listed among the discharge diagnoses were recorded using Professional Standards Review Organization data tapes A ten percent random sample of all recorded diagnoses were validated yearly by abstracting data from hospital records Each years validation sample of definite and probable cases of myocardial infarction and stroke formed a cohort to be followed for mortality for one year after the onset of the disease event Individual hospitals and the Professional Standards Review Organization in the area provided data on the total numbers of coronary care unit admissions and coronary artery bypass operations for each year Beginning in August 1988 a registry was established for all new incident cases of coronary heart disease at the University of Minnesota Hospital and the Ramsey County Hospital In 1989 twelve hospitals were part of the myocardial infarction registry
Risk Factor Surveillance Population samples aged 25-74 years are recruited and measured for blood pressure serum cholesterol serum high density lipoprotein cholesterol cigarette smoking diet physical activity height weight health attitudes and beliefs and coronary prone behavior Surveys were completed in 1980-1982 and 1984-1985 The third survey conducted in 1990-1992 included the Willett Food Frequency Questionnaire and bioimpedance measurements A nested case-control study using the 1980-1982 risk factor cohort examined the baseline cardiovascular disease risk factor differences between coronary heart disease in cases and controls
The study was renewed in the year 2000 under R01HL23727 to conduct a population survey of 4000 adults ages 25 to 84 in 2000-2002 to detect current trends in cardiovascular disease risk factors including serum lipids blood pressure cigarette smoking prevalence dietary fat intake obesity diabetes physical inactivity fibrinogen and serum vitamin E Cohort and ecological analyses will be used to link secular trends in risk factors to morbidity and mortality from coronary heart disease congestive heart failure and stroke A total of 1000 children and adolescents ages 8-17 will also be surveyed using youth-specific measurement instruments where appropriate
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL023727 | NIH | None | httpsreporternihgovquickSearchR01HL023727 |