Ignite Creation Date:
2024-05-06 @ 7:04 PM
Last Modification Date:
2024-10-26 @ 3:00 PM
Study NCT ID:
NCT05888129
Status:
COMPLETED
Last Update Posted:
2023-06-05
First Post:
2023-05-09
Brief Title:
Clinical Outcomes of Surgery After Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Cancer
Sponsor:
Asan Medical Center
Organization:
Asan Medical Center
Study Overview
Official Title:
Clinical Outcomes of Surgery After Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Ductal Adenocarcinoma is it Really Comparable to Borderline Resectable or Resectable Pancreatic Adenocarcinoma
Status:
COMPLETED
Status Verified Date:
2023-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
COSNALAP
Brief Summary:
The purpose of this study was to investigate the clinical outcomes of patients with locally advanced pancreatic cancer LA-PC who underwent surgery after neoadjuvant chemotherapy NACT at Asan Medical Centers Department of Hepato-Biliary-Pancreatic Surgery from 2017 to 2020
Detailed Description:
Pancreatic cancer PC has a very low survival rate Most PC patients have non-specific symptoms that are advanced enough to be contraindications for surgical treatment therefore surgery is often impossible by the time PC is diagnosed According to the NCCN guidelines PCs with no metastases can be divided into resectable borderline resectable and locally advanced cases Patients with borderline resectable PC BR-PC and locally advanced PC LA-PC currently receive multimodal therapy before surgery The goal of these neoadjuvant treatments including chemotherapy and radiation therapy is to ultimately reduce local recurrence after surgery in patients with BR-PC and further improve their survival time Additionally several recent studies have reported results on the prognosis when surgery is performed after neoadjuvant chemotherapy NACT in patients with LA-PC In the patients with LA-PC surgery technically difficult because of major vascular invasion before NACT Therefore this study investigated the clinical outcomes of patients with LA-PC who underwent surgery after NACT Additionally the investigators evaluated factors affecting the prognosis related to survival after surgery in patients with LA-PC
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None