Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00005485
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2024-04-24
First Post:
2000-05-25
Brief Title:
The Jackson Heart Study of Cardiovascular Disease Among African Americans
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
The Jackson Heart Study of Cardiovascular Disease Among African Americans
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2024-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
JHS
Brief Summary:
This is a prospective study of the environmental and genetic factors that influence the development of cardiovascular disease CVD in African American men and women The cohort is a collaboration among multiple institutions Jackson State University Mississippi State Department of Health Tougaloo College and the University of Mississippi Medical Center the National Institute on Minority Health and Health Disparities NIMHD and the National Heart Lung and Blood Institute NHLBI
Detailed Description:
The Jackson Heart Study JHS initiated in 1998 is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease CVD in African Americans In addition the JHS conducts community education and outreach activities to promote healthy lifestyles and reduce disease risk burden undergraduate- and graduate-level research training programs and high school science and math enrichment programs to prepare and encourage students from underrepresented racialethnic groups to pursue biomedical careers The study recruited 5306 African-American residents living in the Jackson MS metropolitan statistical area of Hinds Madison and Rankin Counties Participants were enrolled from each of 4 recruitment pools random 17 volunteer 30 currently enrolled in the Atherosclerosis Risk in Communities ARIC Study 31 shared JHSARIC cohort and secondary family members 22 Recruitment was limited to non-institutionalized adult African Americans aged 35-84 years except in a nested family cohort where those 21 to 34 years of age were also eligible The final cohort included 659 of all African American residents in the Jackson MSA aged 35-84 during the baseline exam N76426 US Census 2000 Among these approximately 3700 gave consent that allows genetic research and deposition of data into dbGaP JHS participants have completed three clinical examinations Exam 1 2000-04 Exam 2 2005-08 and Exam 3 2009-13 that have generated extensive longitudinal data on traditional and putative CVD risk factors socioeconomic and sociocultural factors biochemical analytes and measures of subclinical disease from echocardiography cardiac magnetic resonance imaging MRI and computed tomography CT scans of the heart aorta and abdomen Stored biological samples have been assayed for putative biochemical risk factors and stored for future research DNA has been extracted and lymphocytes cryopreserved for study of candidate genes genome-wide scanning expression and other -omics investigations Participants have been contacted annually to update information confirm vital status document interim medical events hospitalizations and functional status and obtain additional sociocultural information Ongoing cohort surveillance includes abstraction of medical records and death certificates for relevant International Classification of Diseases ICD codes and adjudication of nonfatal events and deaths The JHS serves as a resource to the scientific community for novel research promotes cardiovascular health in the local community and encourages underrepresented minority students to pursue biomedical careers
Exam 4 began in 2020 and is ongoing Data collection for the current exam includes anthropometrics blood pressure urine and blood samples echocardiogram electrocardiogram neurocognitive battery physical function interviews and brain MRI
Exam 4 began in 2020 and is ongoing Data collection for the current exam includes anthropometrics blood pressure urine and blood samples echocardiogram electrocardiogram neurocognitive battery physical function interviews and brain MRI
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| HHSN268201800015I | OTHER_GRANT | NHLBI and NIMHD | None |
| HHSN268201800010I | OTHER_GRANT | None | None |
| HHSN268201800011I | OTHER_GRANT | None | None |
| HHSN268201800012I | OTHER_GRANT | None | None |
| HHSN268201800013I | OTHER_GRANT | None | None |
| HHSN268201800014I | OTHER_GRANT | None | None |