Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:04 AM
Study NCT ID:
NCT00005201
Status:
COMPLETED
Last Update Posted:
2016-05-13
First Post:
2000-05-25
Brief Title:
Idiopathic Dilated Cardiomyopathy
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2000-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To determine the familial occurrence and pathogenesis of idiopathic dilated cardiomyopathy
Detailed Description:
BACKGROUND
In 1987 idiopathic dilated cardiomyopathy was a disorder of unknown cause that directly affected one or both cardiac ventricles in a diffuse or multifactorial fashion and that produced heart failure at least in some patients Although a viral etiology had been proposed dilated cardiomyopathy could be associated with numerous genetic and non-genetic diseases However in 1987 the role of genetic factors was not known in humans Although the condition was usually dismissed as sporadic numerous families with multiple affected members have been observed
The role of atrial natriuretic peptide levels in the pathogenesis or progression of idiopathic dilated cardiomyopathy was just beginning to be explored in 1987 Although Syrian hamster studies did not suggest a genetic deficiency as the primary cause of dilated cardiomyopathy in that model it was thought possible that ANP production or levels were somehow involved in how the myocardium responds in idiopathic dilated cardiomyopathy patients
DESIGN NARRATIVE
Eligible patients were interviewed and asked whether any first-degree relatives were willing to participate If family members participated a three generation pedigree was constructed and first-degree relatives contacted The relatives were interviewed for a medical history and medical records from other institutions were reviewed Each family member had a brief cardiovascular examination a 12-lead electrocardiogram and 2-dimensional M-mode and Doppler echocardiogram Blood was drawn for determination of atrial natriuretic peptide ANP levels The contributions of variability in age sex drug use smoking and other concomitants to variability in ANP and echocardiographic data were estimated After removing these sources of variability the strength of similarity among family members was assessed The relative contributions of genes and shared environments to the similarity among family members were estimated
Heterogeneity in the mean levels of echocardiographic indices and ANP levels familial aggregation and etiology of aggregation were assessed between families with familial idiopathic dilated cardiomyopathy and families with non-familial idiopathic dilated cardiomyopathy
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
In 1987 idiopathic dilated cardiomyopathy was a disorder of unknown cause that directly affected one or both cardiac ventricles in a diffuse or multifactorial fashion and that produced heart failure at least in some patients Although a viral etiology had been proposed dilated cardiomyopathy could be associated with numerous genetic and non-genetic diseases However in 1987 the role of genetic factors was not known in humans Although the condition was usually dismissed as sporadic numerous families with multiple affected members have been observed
The role of atrial natriuretic peptide levels in the pathogenesis or progression of idiopathic dilated cardiomyopathy was just beginning to be explored in 1987 Although Syrian hamster studies did not suggest a genetic deficiency as the primary cause of dilated cardiomyopathy in that model it was thought possible that ANP production or levels were somehow involved in how the myocardium responds in idiopathic dilated cardiomyopathy patients
DESIGN NARRATIVE
Eligible patients were interviewed and asked whether any first-degree relatives were willing to participate If family members participated a three generation pedigree was constructed and first-degree relatives contacted The relatives were interviewed for a medical history and medical records from other institutions were reviewed Each family member had a brief cardiovascular examination a 12-lead electrocardiogram and 2-dimensional M-mode and Doppler echocardiogram Blood was drawn for determination of atrial natriuretic peptide ANP levels The contributions of variability in age sex drug use smoking and other concomitants to variability in ANP and echocardiographic data were estimated After removing these sources of variability the strength of similarity among family members was assessed The relative contributions of genes and shared environments to the similarity among family members were estimated
Heterogeneity in the mean levels of echocardiographic indices and ANP levels familial aggregation and etiology of aggregation were assessed between families with familial idiopathic dilated cardiomyopathy and families with non-familial idiopathic dilated cardiomyopathy
The study completion date listed in this record was obtained from the End Date entered in the Protocol Registration and Results System PRS record
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01HL036879 | NIH | None | httpsreporternihgovquickSearchR01HL036879 |