Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001887
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Factors Involved in Asthma and Airway Inflammation
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
The Role of a Novel Aminopeptidase-Like Protein in Asthma
Status:
COMPLETED
Status Verified Date:
2000-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Asthma is the third leading cause of preventable admissions to the hospital in the United States Deaths and diseases associated with asthma increase every year Asthma is a disorder of airway inflammation There are several factors thought to play a role in the process of inflammation
In this study researchers are particularly interested in studying a factors known as TNF tumor necrosis factor and the sites where this factor attaches called receptors Another factor associated with receptor processing is called aminopeptidase-like protein It may be involved in the relationship between TNF its receptors and inflammation
In order to understand the relationship between these factors researchers plan to simulate an allergic reaction in the lungs and airways of patients participating in the study By doing this they can collect and study the factors causing airway inflammation Samples collected from patients with asthma will be compared to samples from volunteers without asthma
Patients and volunteers participating in this study will not directly benefit from this research However the study may help researchers understand the causes and processes involved in asthma In addition the study may lead to the development of new treatments for asthma and airway inflammation
In this study researchers are particularly interested in studying a factors known as TNF tumor necrosis factor and the sites where this factor attaches called receptors Another factor associated with receptor processing is called aminopeptidase-like protein It may be involved in the relationship between TNF its receptors and inflammation
In order to understand the relationship between these factors researchers plan to simulate an allergic reaction in the lungs and airways of patients participating in the study By doing this they can collect and study the factors causing airway inflammation Samples collected from patients with asthma will be compared to samples from volunteers without asthma
Patients and volunteers participating in this study will not directly benefit from this research However the study may help researchers understand the causes and processes involved in asthma In addition the study may lead to the development of new treatments for asthma and airway inflammation
Detailed Description:
The goal of this exploratory study is to assess the role of a novel aminopeptidase-like protein during the induction of airway inflammation in asthma This aminopeptidase-like protein may be involved in processing of the type I TNF receptor to a soluble form We propose to study the role of this aminopeptidase-like protein in the setting of late phase asthmatic airway inflammatory responses following segmental allergen challenge in mild allergic asthmatics
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 99-H-0075 | None | None | None |