Ignite Creation Date:
2024-05-05 @ 11:21 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001741
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Study of Inherited Changes of Receptors Located on Blood Vessels
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Study of Vascular Responsiveness in Subjects With Polymorphisms of the Angiotensin II Type I Receptor Gene
Status:
COMPLETED
Status Verified Date:
2003-04
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The renin angiotensin system is a complex process involving hormones and enzymes that regulate blood volume and blood pressure The hormone angiotensin II is responsible for making blood vessels narrow or constrict Angiotensin II is found in the blood and can attach to special sites called receptors on blood vessel walls These receptors are programmed to accept angiotensin II and cause a constriction of the blood vessel This function is found in the genetic information of each individual person
Occasionally patients have changes in their genes related to angiotensin II receptors These changes may result in the receptors acting differently to angiotensin II which may affect the function of blood vessels
This study is designed to improve researchers understanding of the physiological effects on blood vessels associated with mutations of the genes responsible for angiotensin II receptor function
Occasionally patients have changes in their genes related to angiotensin II receptors These changes may result in the receptors acting differently to angiotensin II which may affect the function of blood vessels
This study is designed to improve researchers understanding of the physiological effects on blood vessels associated with mutations of the genes responsible for angiotensin II receptor function
Detailed Description:
Polymorphisms in the genes encoding for various elements of the renin angiotensin system have been associated with cardiovascular disease We have isolated novel alleles in the angiotensin II type I receptor gene We propose this exploratory investigation to study the physiological effect of these mutations on vascular function in patients and family members who carry these rare alleles
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 98-H-0029 | None | None | None |