Ignite Creation Date:
2024-05-06 @ 7:23 PM
Last Modification Date:
2024-10-26 @ 3:06 PM
Study NCT ID:
NCT05995067
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2023-12-12
First Post:
2023-08-08
Brief Title:
The Potential Association of Long Non-coding RNA NEAT1 and MALAT1 in the Process of Epithelial-mesenchymal Transition in Periodontitis
Sponsor:
Ali A Abdulkareem
Organization:
University of Baghdad
Study Overview
Official Title:
The Potential Association of Long Non-coding RNA NEAT1 and MALAT1 in the Process of Epithelial-mesenchymal Transition in Periodontitis
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2023-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Periodontitis is a polymicrobial inflammatory condition affecting tooth-supporting tissues It is characterized by a progressive loss of epithelial attachment and resorption of alveolar bone which can lead to tooth loss Epithelial-mesenchymal transition EMT has been proposed as a reversible process that shifts the cell phenotype from epithelial to mesenchymal-like and may be involved in the process of periodontal inflammation either completely or partially Long non-coding RNAs lncRNAs are a large class of regulatory transcripts longer than 200 nucleotides lacking evident protein-coding potential Studies have shown that lncRNA dysregulation plays key roles in human diseases including cancer by modulating the epithelial-mesenchymal transition EMT The involvement of lncRNAs markers in the pathogenesis of periodontal disease induced EMT has not been studied thoroughly and have created a gap in the knowledge
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None