Ignite Creation Date:
2024-05-06 @ 7:25 PM
Last Modification Date:
2024-10-26 @ 3:06 PM
Study NCT ID:
NCT06000137
Status:
COMPLETED
Last Update Posted:
2023-08-21
First Post:
2023-05-04
Brief Title:
The Comparison of the Analgesic Effects of Dezocine and Sufentanil in Patient-controlled Analgesia After Laryngectomy
Sponsor:
Eye ENT Hospital of Fudan University
Organization:
Eye ENT Hospital of Fudan University
Study Overview
Official Title:
The Comparison of the Analgesic Effects of Dezocine and Sufentanil in Patient-controlled Analgesia After Laryngectomy
Status:
COMPLETED
Status Verified Date:
2023-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Laryngeal cancer is one of the most common tumors in otolaryngology In China it accounts for 1-5 of all malignancies and has an incidence of 113 per 100000 Surgical resection is the most important treatment for patients who are not candidates for chemoradiotherapy or refuse chemoradiotherapy The types of surgery include total and partial laryngectomy Patients with laryngeal cancer often face multiple physical and psychiatric changes after surgery such as daily large sputum production accompanied by cough cleaning care of the air incision fatigue and sleep disturbances Some patients do not actively exclude secretions due to pain and the formation of sputum plugs causes lung inflammation which is not conducive to postoperative recovery Good postoperative pain management is beneficial to shorten the length of hospital stay and reduce mortality Sufentanil is most commonly used for postoperative analgesia and has good analgesic effect but there are some adverse effects such as dizziness nausea and vomiting urinary retention skin itching respiratory depression etc As a new type of analgesic dezocine has been widely used in clinical practice with few adverse reactions to the respiratory and circulatory system and its application to postoperative analgesia can significantly improve the immune activity At present there are not many studies on continuous analgesia of dezocine mostly single-dose analgesia studies this study for different doses of dezocine for the postoperative analgesic effect of laryngeal cancer patients compared with the current classic opioid analgesics to provide a new scheme for clinical medication
Detailed Description:
Laryngeal cancer is one of the most common tumors in otolaryngology In China it accounts for 1-5 of all malignancies and has an incidence of 113 per 100000 Surgical resection is the most important treatment for patients who are not candidates for chemoradiotherapy or refuse chemoradiotherapy The types of surgery include total and partial laryngectomy Patients with laryngeal cancer often face multiple physical and psychiatric changes after surgery such as daily large sputum production accompanied by cough cleaning care of the air incision fatigue and sleep disturbances In patients with laryngeal cancer large amounts of secretions can cause frequent coughing even wheezing and coughing can exacerbate the degree of postoperative pain Some patients do not actively exclude secretions due to pain and the formation of sputum plugs causes lung inflammation which is not conducive to postoperative recovery In addition the inability to verbalize after laryngeal cancer surgery puts patients in a state of anxiety which increases the degree of postoperative pain Good postoperative pain management is beneficial to shorten the length of hospital stay and reduce mortality Sufentanil is most commonly used for postoperative analgesia and has good analgesic effect but there are some adverse effects such as dizziness nausea and vomiting urinary retention skin itching respiratory depression etc As a new type of analgesic dezocine has been widely used in clinical practice with few adverse reactions to the respiratory and circulatory system and its application to postoperative analgesia can significantly improve the immune activity At present there are not many studies on continuous analgesia of dezocine mostly single-dose analgesia studies this study for different doses of dezocine for the postoperative analgesic effect of laryngeal cancer patients compared with the current classic opioid analgesics to provide a new scheme for clinical medication
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None